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Interaction between hydrogen peroxide and titanium: a possible role in the biocompatibility of titanium

Tengvall, Pentti; Elwing, Hans; Sjöqvist, Lars; Lundström, Ingemar and Bjursten, Lars Magnus LU (1989) In Biomaterials 10(2). p.118-120
Abstract
Hydroxyl radicals formed from hydrogen peroxide during an inflammatory response are potent agents for cellular deterioration. The behaviour of implanted material in terms of its ability to sustain or stop free radical formation may be therefore very important. In vitro studies of titanium which is known to be biocompatible and osseointegrates into human bone were carried out. In our model studies, the production of free radicals from H2O2 at Ti and TiO2 surfaces was measured by spin trapping techniques. Our findings suggest that there is no sustained hydroxyl radical production at a titanium (oxide) surface. We propose that this is due to the quenching of the Fenton reaction through both trapping and oxidation of superoxide radicals in a... (More)
Hydroxyl radicals formed from hydrogen peroxide during an inflammatory response are potent agents for cellular deterioration. The behaviour of implanted material in terms of its ability to sustain or stop free radical formation may be therefore very important. In vitro studies of titanium which is known to be biocompatible and osseointegrates into human bone were carried out. In our model studies, the production of free radicals from H2O2 at Ti and TiO2 surfaces was measured by spin trapping techniques. Our findings suggest that there is no sustained hydroxyl radical production at a titanium (oxide) surface. We propose that this is due to the quenching of the Fenton reaction through both trapping and oxidation of superoxide radicals in a TiOOH adduct. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Titanium, hydrogen peroxide, oxygen radicals, biocompatibility
in
Biomaterials
volume
10
issue
2
pages
118 - 120
publisher
Elsevier
external identifiers
  • pmid:2706298
  • scopus:0024598059
ISSN
1878-5905
DOI
10.1016/0142-9612(89)90043-4
language
English
LU publication?
no
id
b5041be7-34b1-46aa-9f1a-75e6fb3438e8 (old id 1104489)
date added to LUP
2008-08-06 09:12:21
date last changed
2017-11-19 03:34:17
@article{b5041be7-34b1-46aa-9f1a-75e6fb3438e8,
  abstract     = {Hydroxyl radicals formed from hydrogen peroxide during an inflammatory response are potent agents for cellular deterioration. The behaviour of implanted material in terms of its ability to sustain or stop free radical formation may be therefore very important. In vitro studies of titanium which is known to be biocompatible and osseointegrates into human bone were carried out. In our model studies, the production of free radicals from H2O2 at Ti and TiO2 surfaces was measured by spin trapping techniques. Our findings suggest that there is no sustained hydroxyl radical production at a titanium (oxide) surface. We propose that this is due to the quenching of the Fenton reaction through both trapping and oxidation of superoxide radicals in a TiOOH adduct.},
  author       = {Tengvall, Pentti and Elwing, Hans and Sjöqvist, Lars and Lundström, Ingemar and Bjursten, Lars Magnus},
  issn         = {1878-5905},
  keyword      = {Titanium,hydrogen peroxide,oxygen radicals,biocompatibility},
  language     = {eng},
  number       = {2},
  pages        = {118--120},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Interaction between hydrogen peroxide and titanium: a possible role in the biocompatibility of titanium},
  url          = {http://dx.doi.org/10.1016/0142-9612(89)90043-4},
  volume       = {10},
  year         = {1989},
}