Advanced

Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.

Lundwall, Åke LU ; Bjartell, Anders LU ; Ceder, Yvonne LU and Malm, Johan LU (2002) In Molecular Human Reproduction 8(9). p.805-810
Abstract
Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII... (More)
Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII transcripts were predominant. By immunohistochemistry, the basal cell layer of the secretory epithelium in prostate, trachea and bronchi was stained by antibodies recognizing both SgI and SgII. This is in contrast to the seminal vesicle and vas deferens, where the luminal cells were stained. The staining of skeletal muscle cells and a few scattered cells in the central nervous system suggests that semenogelin expression is not restricted to epithelial cells. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Human Reproduction
volume
8
issue
9
pages
805 - 810
publisher
Oxford University Press
external identifiers
  • pmid:12200457
  • wos:000177970900003
  • scopus:0036713173
ISSN
1460-2407
language
English
LU publication?
yes
id
209d5953-85b3-4d8d-ab27-91079ccd946a (old id 110449)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12200457&dopt=Abstract
date added to LUP
2007-07-26 09:50:31
date last changed
2017-11-05 03:28:46
@article{209d5953-85b3-4d8d-ab27-91079ccd946a,
  abstract     = {Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII transcripts were predominant. By immunohistochemistry, the basal cell layer of the secretory epithelium in prostate, trachea and bronchi was stained by antibodies recognizing both SgI and SgII. This is in contrast to the seminal vesicle and vas deferens, where the luminal cells were stained. The staining of skeletal muscle cells and a few scattered cells in the central nervous system suggests that semenogelin expression is not restricted to epithelial cells.},
  author       = {Lundwall, Åke and Bjartell, Anders and Ceder, Yvonne and Malm, Johan},
  issn         = {1460-2407},
  language     = {eng},
  number       = {9},
  pages        = {805--810},
  publisher    = {Oxford University Press},
  series       = {Molecular Human Reproduction},
  title        = {Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.},
  volume       = {8},
  year         = {2002},
}