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Infections and antibiotic prophylaxis in reconstructive vascular surgery

Herbst, Andreas LU ; Kamme, Carl; Norgren, Lars LU ; Qvarfordt, Peter; Ribbe, Else LU and Thörne, Johan LU (1989) In European Journal of Vascular Surgery 3(4). p.303-307
Abstract
In 98 patients undergoing elective vascular surgery, specimens for bacterial cultures were obtained from urine, ischaemic ulcers, incisional wounds and the implanted grafts. Wound and graft infections were registered and compared with the results of these cultures and suspected risk factors in an attempt to find the source of infections. Antibiotic prophylaxis with cefuroxime was given for 24 h beginning at the start of surgery. Patients with ischaemic ulcers also received "spread prophylaxis", directed against isolated bacteria, for ten days. Three cases of graft infection and twelve cases of wound infection occurred. Positive postoperative cultures from wounds did not correlate with pre- or peroperative cultures. Peroperative cultures... (More)
In 98 patients undergoing elective vascular surgery, specimens for bacterial cultures were obtained from urine, ischaemic ulcers, incisional wounds and the implanted grafts. Wound and graft infections were registered and compared with the results of these cultures and suspected risk factors in an attempt to find the source of infections. Antibiotic prophylaxis with cefuroxime was given for 24 h beginning at the start of surgery. Patients with ischaemic ulcers also received "spread prophylaxis", directed against isolated bacteria, for ten days. Three cases of graft infection and twelve cases of wound infection occurred. Positive postoperative cultures from wounds did not correlate with pre- or peroperative cultures. Peroperative cultures revealed small numbers of staphylococcus epidermidis in eleven patients, and none of them developed graft infection. Ischaemic ulcers, diabetes or re-do procedures were not accompanied by a significantly increased frequency of wound or graft infection, although each of three patients with graft infection had one of these risk factors. Bacteria, sensitive to cefuroxime, were found in one graft infection, six wound infections, and in two patients with urosepsis, whereas cefuroxime resistant organisms were isolated from one graft infection and three infected wounds. One of the three graft infections was probably caused by bacteria originating from the patient's ischaemic ulcer. In the other two patients the source of bacteria could not be determined. Cefuroxime seems to be an adequate alternative for prophylaxis of vascular graft infection, but in some patients with bacteriuria or indwelling catheters, a one day regimen may be too short. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vascular Surgery, Infection, Grafts, Cefuroxime
in
European Journal of Vascular Surgery
volume
3
issue
4
pages
303 - 307
publisher
Elsevier
external identifiers
  • pmid:2767253
  • scopus:0024459694
ISSN
0950-821X
DOI
10.1016/S0950-821X(89)80065-9
language
English
LU publication?
yes
id
976fc52c-4c19-4bf9-b5f4-d1e8f40bf31f (old id 1104506)
date added to LUP
2008-08-06 09:23:22
date last changed
2017-08-06 04:29:51
@article{976fc52c-4c19-4bf9-b5f4-d1e8f40bf31f,
  abstract     = {In 98 patients undergoing elective vascular surgery, specimens for bacterial cultures were obtained from urine, ischaemic ulcers, incisional wounds and the implanted grafts. Wound and graft infections were registered and compared with the results of these cultures and suspected risk factors in an attempt to find the source of infections. Antibiotic prophylaxis with cefuroxime was given for 24 h beginning at the start of surgery. Patients with ischaemic ulcers also received "spread prophylaxis", directed against isolated bacteria, for ten days. Three cases of graft infection and twelve cases of wound infection occurred. Positive postoperative cultures from wounds did not correlate with pre- or peroperative cultures. Peroperative cultures revealed small numbers of staphylococcus epidermidis in eleven patients, and none of them developed graft infection. Ischaemic ulcers, diabetes or re-do procedures were not accompanied by a significantly increased frequency of wound or graft infection, although each of three patients with graft infection had one of these risk factors. Bacteria, sensitive to cefuroxime, were found in one graft infection, six wound infections, and in two patients with urosepsis, whereas cefuroxime resistant organisms were isolated from one graft infection and three infected wounds. One of the three graft infections was probably caused by bacteria originating from the patient's ischaemic ulcer. In the other two patients the source of bacteria could not be determined. Cefuroxime seems to be an adequate alternative for prophylaxis of vascular graft infection, but in some patients with bacteriuria or indwelling catheters, a one day regimen may be too short.},
  author       = {Herbst, Andreas and Kamme, Carl and Norgren, Lars and Qvarfordt, Peter and Ribbe, Else and Thörne, Johan},
  issn         = {0950-821X},
  keyword      = {Vascular Surgery,Infection,Grafts,Cefuroxime},
  language     = {eng},
  number       = {4},
  pages        = {303--307},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular Surgery},
  title        = {Infections and antibiotic prophylaxis in reconstructive vascular surgery},
  url          = {http://dx.doi.org/10.1016/S0950-821X(89)80065-9},
  volume       = {3},
  year         = {1989},
}