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Use of ciprofloxacin in patients undergoing transurethral prostatic surgery

Hellsten, Sverker LU ; Forsgren, Arne LU ; Björk, Thomas LU and Grabe, Magnus LU (1989) In Scandinavian Journal of Infectious Diseases. Supplementum 60. p.104-107
Abstract
The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection and compared with that of controls without antibiotic (Group III). Both regimens significantly reduced the frequency of post-operative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) compared to the controls. Both regimens were equally effective in preventing peri-operative and post-operative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found post-operatively in 35% in Group I and in 9% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin... (More)
The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection and compared with that of controls without antibiotic (Group III). Both regimens significantly reduced the frequency of post-operative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) compared to the controls. Both regimens were equally effective in preventing peri-operative and post-operative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found post-operatively in 35% in Group I and in 9% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally, ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases. Supplementum
volume
60
pages
104 - 107
publisher
Scandinavian University Press
external identifiers
  • pmid:2756349
  • scopus:0024308569
ISSN
0300-8878
language
English
LU publication?
yes
id
f75a7e90-c91e-486f-b690-86f6a3f2dfb1 (old id 1104523)
date added to LUP
2008-08-06 09:36:36
date last changed
2017-01-01 07:01:45
@article{f75a7e90-c91e-486f-b690-86f6a3f2dfb1,
  abstract     = {The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection and compared with that of controls without antibiotic (Group III). Both regimens significantly reduced the frequency of post-operative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) compared to the controls. Both regimens were equally effective in preventing peri-operative and post-operative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found post-operatively in 35% in Group I and in 9% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally, ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.},
  author       = {Hellsten, Sverker and Forsgren, Arne and Björk, Thomas and Grabe, Magnus},
  issn         = {0300-8878},
  language     = {eng},
  pages        = {104--107},
  publisher    = {Scandinavian University Press},
  series       = {Scandinavian Journal of Infectious Diseases. Supplementum},
  title        = {Use of ciprofloxacin in patients undergoing transurethral prostatic surgery},
  volume       = {60},
  year         = {1989},
}