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Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels

Suzuki, Norihiro ; Hardebo, Jan Erik LU ; Kåhrstrom, Jan and Owman, Christer LU (1989) In Neuroscience Letters 100(1-3). p.123-129
Abstract
(GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibres in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial... (More)
(GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibres in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial arteries, neither in normal nor in sympathectomized animals, which rules out a direct postsynaptic effect on vascular tone. GAL did not display prejunctional modulatory action on the adrenergic nerves present in the vascular preparations. A sensory function of GAL is discussed. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Galanin, Cerebral vessel, Sensory nerve fiber, Sympathectomy, Immunohistochemistry, Neuropeptide
in
Neuroscience Letters
volume
100
issue
1-3
pages
123 - 129
publisher
Elsevier
external identifiers
  • pmid:2474775
  • scopus:0024590238
ISSN
0304-3940
DOI
10.1016/0304-3940(89)90671-X
language
English
LU publication?
yes
id
dc90b04f-8631-4228-9904-d635947414b4 (old id 1104677)
date added to LUP
2016-04-01 12:23:34
date last changed
2021-08-29 04:23:29
@article{dc90b04f-8631-4228-9904-d635947414b4,
  abstract     = {{(GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibres in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial arteries, neither in normal nor in sympathectomized animals, which rules out a direct postsynaptic effect on vascular tone. GAL did not display prejunctional modulatory action on the adrenergic nerves present in the vascular preparations. A sensory function of GAL is discussed.}},
  author       = {{Suzuki, Norihiro and Hardebo, Jan Erik and Kåhrstrom, Jan and Owman, Christer}},
  issn         = {{0304-3940}},
  keywords     = {{Galanin; Cerebral vessel; Sensory nerve fiber; Sympathectomy; Immunohistochemistry; Neuropeptide}},
  language     = {{eng}},
  number       = {{1-3}},
  pages        = {{123--129}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels}},
  url          = {{http://dx.doi.org/10.1016/0304-3940(89)90671-X}},
  doi          = {{10.1016/0304-3940(89)90671-X}},
  volume       = {{100}},
  year         = {{1989}},
}