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Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when compared with standard investigations

Schmiegelow, Kjeld; Simes, Martti A; Agertoft, Lone; Berglund, Gunilla; Storm-Mathisen, Ingebjörn; Andreassen, Michael; Salmi, Toivo T; Nygard, Randi; Wiebe, Thomas LU and Kreuger, Anders, et al. (1989) In Medical and Pediatric Oncology 17(2). p.126-130
Abstract
Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy... (More)
Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy. (Less)
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Contribution to journal
publication status
published
subject
keywords
MIBG scintigraphy, sensitivity, specificity, predictive value
in
Medical and Pediatric Oncology
volume
17
issue
2
pages
126 - 130
publisher
John Wiley & Sons
external identifiers
  • pmid:2649775
  • scopus:0024526167
ISSN
1096-911X
DOI
10.1002/mpo.2950170210
language
English
LU publication?
yes
id
20cb017b-294b-4052-8745-02ce0a9bf8e3 (old id 1104695)
date added to LUP
2008-08-06 13:38:29
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2017-03-05 03:25:13
@article{20cb017b-294b-4052-8745-02ce0a9bf8e3,
  abstract     = {Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy.},
  author       = {Schmiegelow, Kjeld and Simes, Martti A and Agertoft, Lone and Berglund, Gunilla and Storm-Mathisen, Ingebjörn and Andreassen, Michael and Salmi, Toivo T and Nygard, Randi and Wiebe, Thomas and Kreuger, Anders and Hayder, Salah},
  issn         = {1096-911X},
  keyword      = {MIBG scintigraphy,sensitivity,specificity,predictive value},
  language     = {eng},
  number       = {2},
  pages        = {126--130},
  publisher    = {John Wiley & Sons},
  series       = {Medical and Pediatric Oncology},
  title        = {Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when compared with standard investigations},
  url          = {http://dx.doi.org/10.1002/mpo.2950170210},
  volume       = {17},
  year         = {1989},
}