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Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes

Geborek, Pierre LU ; Forslind, K and Wollheim, Frank LU (1989) In Annals of the Rheumatic Diseases 48(4). p.281-286
Abstract
A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laser Doppler technique, rheumatoid arthritis
in
Annals of the Rheumatic Diseases
volume
48
issue
4
pages
281 - 286
publisher
British Medical Association
external identifiers
  • pmid:2653243
  • scopus:0024521138
ISSN
1468-2060
DOI
10.1136/ard.48.4.281
language
English
LU publication?
yes
id
c679cc6a-c51d-4b59-a2ee-4b565cf29058 (old id 1104724)
date added to LUP
2008-08-06 14:06:55
date last changed
2017-08-27 05:13:15
@article{c679cc6a-c51d-4b59-a2ee-4b565cf29058,
  abstract     = {A method for measuring synovial blood flow changes using the laser Doppler technique is described. Mean blood flow and mean pulse amplitude decreased by 50-70% in relation to the reference level when the intra-articular hydrostatic pressure in effusive knee joints of patients with rheumatoid arthritis was increased. As an increase of intra-articular pressure of as little as 20 mmHg decreased synovial blood flow significantly it is suggested that hypoxia may occur in vivo during joint use in the presence of an effusion. This may be of aetiopathogenetic importance for tissue destruction and the persistence of chronic synovitis.},
  author       = {Geborek, Pierre and Forslind, K and Wollheim, Frank},
  issn         = {1468-2060},
  keyword      = {laser Doppler technique,rheumatoid arthritis},
  language     = {eng},
  number       = {4},
  pages        = {281--286},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes},
  url          = {http://dx.doi.org/10.1136/ard.48.4.281},
  volume       = {48},
  year         = {1989},
}