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Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.

Nilbert, Mef LU ; Heim, Sverre LU ; Mandahl, Nils LU ; Flodérus, Ulla-Maria; Willén, Helena; Baldetorp, Bo LU and Mitelman, Felix LU (1989) In Genes, Chromosomes and Cancer 1(2). p.131-134
Abstract
Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating... (More)
Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
1
issue
2
pages
131 - 134
publisher
John Wiley & Sons
external identifiers
  • scopus:0024910245
ISSN
1045-2257
DOI
10.1002/gcc.2870010204
language
English
LU publication?
yes
id
f041931d-1f6f-4b4f-90ae-e7feeeee85d0 (old id 1104766)
date added to LUP
2008-08-06 14:44:02
date last changed
2017-07-30 03:50:57
@article{f041931d-1f6f-4b4f-90ae-e7feeeee85d0,
  abstract     = {Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44, XX,-6,-7,-10,-11,+20,-22, r(1), der(2) (:2p23cen2q13::1q211qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.},
  author       = {Nilbert, Mef and Heim, Sverre and Mandahl, Nils and Flodérus, Ulla-Maria and Willén, Helena and Baldetorp, Bo and Mitelman, Felix},
  issn         = {1045-2257},
  language     = {eng},
  number       = {2},
  pages        = {131--134},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.},
  url          = {http://dx.doi.org/10.1002/gcc.2870010204},
  volume       = {1},
  year         = {1989},
}