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Age dependence of renal function: clearance of iohexol and p-amino hippurate in healthy males

Back, S E; Ljungberg, Bengt LU ; Nilsson-Ehle, Ingrid LU ; Borga, O and Nilsson-Ehle, Peter LU (1989) In Scandinavian Journal of Clinical & Laboratory Investigation 49(7). p.641-646
Abstract
Iohexol, a newly developed non-ionic contrast agent, has been recently documented as a reliable glomerular filtration marker. This study describes the age dependence of the single injection clearance of iohexol in a sample of healthy male volunteers ranging from 21 to 77 years of age. In parallel, renal plasma flow was studied by measuring the total clearance of p-amino hippuric acid administered as a continuous infusion. In subjects older than 50 years a negative correlation to age was found for both p-amino hippuric acid and iohexol clearance, with a reduction of 52 ml/min and 12 ml/min per decade, respectively, whereas no age dependence was found for younger subjects. Correlation between p-amino hippuric acid and iohexol clearances was... (More)
Iohexol, a newly developed non-ionic contrast agent, has been recently documented as a reliable glomerular filtration marker. This study describes the age dependence of the single injection clearance of iohexol in a sample of healthy male volunteers ranging from 21 to 77 years of age. In parallel, renal plasma flow was studied by measuring the total clearance of p-amino hippuric acid administered as a continuous infusion. In subjects older than 50 years a negative correlation to age was found for both p-amino hippuric acid and iohexol clearance, with a reduction of 52 ml/min and 12 ml/min per decade, respectively, whereas no age dependence was found for younger subjects. Correlation between p-amino hippuric acid and iohexol clearances was 0.81. However, the filtration fraction, defined as the ratio of iohexol to p-amino hippuric acid clearance, was higher in the elderly subjects. A consistent discrepancy was found between total and renal clearances of p-amino hippuric acid, indicating significant renal metabolism. Renal clearance of creatinine was poorly correlated to iohexol clearance and did not show any relationship to age. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
iohexol clearance, p-amino hippurate clearance, renal plasma flow, creatinine clearance, glomerular filtration rate, aged, age dependence
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
49
issue
7
pages
641 - 646
publisher
Informa Healthcare
external identifiers
  • pmid:2609107
  • scopus:0024469548
ISSN
1502-7686
DOI
10.3109/00365518909091539
language
English
LU publication?
yes
id
ebeb28d9-ece7-4df4-b3b8-75e10de14290 (old id 1104777)
date added to LUP
2008-08-06 14:56:04
date last changed
2017-08-20 04:33:27
@article{ebeb28d9-ece7-4df4-b3b8-75e10de14290,
  abstract     = {Iohexol, a newly developed non-ionic contrast agent, has been recently documented as a reliable glomerular filtration marker. This study describes the age dependence of the single injection clearance of iohexol in a sample of healthy male volunteers ranging from 21 to 77 years of age. In parallel, renal plasma flow was studied by measuring the total clearance of p-amino hippuric acid administered as a continuous infusion. In subjects older than 50 years a negative correlation to age was found for both p-amino hippuric acid and iohexol clearance, with a reduction of 52 ml/min and 12 ml/min per decade, respectively, whereas no age dependence was found for younger subjects. Correlation between p-amino hippuric acid and iohexol clearances was 0.81. However, the filtration fraction, defined as the ratio of iohexol to p-amino hippuric acid clearance, was higher in the elderly subjects. A consistent discrepancy was found between total and renal clearances of p-amino hippuric acid, indicating significant renal metabolism. Renal clearance of creatinine was poorly correlated to iohexol clearance and did not show any relationship to age.},
  author       = {Back, S E and Ljungberg, Bengt and Nilsson-Ehle, Ingrid and Borga, O and Nilsson-Ehle, Peter},
  issn         = {1502-7686},
  keyword      = {iohexol clearance,p-amino hippurate clearance,renal plasma flow,creatinine clearance,glomerular filtration rate,aged,age dependence},
  language     = {eng},
  number       = {7},
  pages        = {641--646},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Age dependence of renal function: clearance of iohexol and p-amino hippurate in healthy males},
  url          = {http://dx.doi.org/10.3109/00365518909091539},
  volume       = {49},
  year         = {1989},
}