Chlorhexidine for prevention of neonatal colonization with group B streptococci. V. Chlorhexidine concentrations in blood following vaginal washing during delivery
(1989) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 31(3). p.221-226- Abstract
- Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine... (More)
- Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine are absorbed through the vaginal mucosa and that chlorhexidine is not accumulated in the blood on repeated usage with 6 hour intervals during delivery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104831
- author
- Nilsson, Gerd LU ; Larsson, Lennart LU ; Kvist Christensen, Karen ; Christensen, Poul and Dykes, Anna-Karin LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chlorhexidine, Vaginal application, Gas chromatography
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 31
- issue
- 3
- pages
- 221 - 226
- publisher
- Elsevier
- external identifiers
-
- pmid:2666181
- scopus:0024385536
- ISSN
- 0301-2115
- DOI
- 10.1016/0028-2243(89)90156-1
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Nursing (Closed 2012) (013065000), Division of Clinical Chemistry and Pharmacology (013250300), Division of Medical Microbiology (013250400)
- id
- e8411cf5-36c1-4bc4-8bda-18f1cc0b59fc (old id 1104831)
- date added to LUP
- 2016-04-01 12:01:25
- date last changed
- 2021-01-03 09:55:01
@article{e8411cf5-36c1-4bc4-8bda-18f1cc0b59fc,
abstract = {{Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine are absorbed through the vaginal mucosa and that chlorhexidine is not accumulated in the blood on repeated usage with 6 hour intervals during delivery.}},
author = {{Nilsson, Gerd and Larsson, Lennart and Kvist Christensen, Karen and Christensen, Poul and Dykes, Anna-Karin}},
issn = {{0301-2115}},
keywords = {{Chlorhexidine; Vaginal application; Gas chromatography}},
language = {{eng}},
number = {{3}},
pages = {{221--226}},
publisher = {{Elsevier}},
series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}},
title = {{Chlorhexidine for prevention of neonatal colonization with group B streptococci. V. Chlorhexidine concentrations in blood following vaginal washing during delivery}},
url = {{http://dx.doi.org/10.1016/0028-2243(89)90156-1}},
doi = {{10.1016/0028-2243(89)90156-1}},
volume = {{31}},
year = {{1989}},
}