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Chlorhexidine for prevention of neonatal colonization with group B streptococci. V. Chlorhexidine concentrations in blood following vaginal washing during delivery

Nilsson, Gerd LU ; Larsson, Lennart LU ; Kvist Christensen, Karen; Christensen, Poul and Dykes, Anna-Karin LU (1989) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 31(3). p.221-226
Abstract
Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine... (More)
Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine are absorbed through the vaginal mucosa and that chlorhexidine is not accumulated in the blood on repeated usage with 6 hour intervals during delivery. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chlorhexidine, Vaginal application, Gas chromatography
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
31
issue
3
pages
221 - 226
publisher
Elsevier
external identifiers
  • pmid:2666181
  • scopus:0024385536
ISSN
0301-2115
DOI
10.1016/0028-2243(89)90156-1
language
English
LU publication?
yes
id
e8411cf5-36c1-4bc4-8bda-18f1cc0b59fc (old id 1104831)
date added to LUP
2008-08-06 15:54:43
date last changed
2017-01-01 04:45:50
@article{e8411cf5-36c1-4bc4-8bda-18f1cc0b59fc,
  abstract     = {Chlorhexidine 2 g/l was applied to the vagina of 96 women during delivery, whereas 28 served as controls. Both groups were given a shower using a chlorhexidine soap, and outer washing of the outer anogenital tract was also performed in all patients using chlorhexidine 2 g/l. Using a gas chromatographic method with a detection limit of 10 ng chlorhexidine per ml blood, 10-83 ng/ml was demonstrated in 34 (35%) of the study group patients, whereas the remaining study group patients and controls showed no detectable chlorhexidine. Performing the washing a second time after 6 hours in 14 patients and a third time in 3 patients after a further 6 hours did not result in increased serum levels. It was concluded that small amounts of chlorhexidine are absorbed through the vaginal mucosa and that chlorhexidine is not accumulated in the blood on repeated usage with 6 hour intervals during delivery.},
  author       = {Nilsson, Gerd and Larsson, Lennart and Kvist Christensen, Karen and Christensen, Poul and Dykes, Anna-Karin},
  issn         = {0301-2115},
  keyword      = {Chlorhexidine,Vaginal application,Gas chromatography},
  language     = {eng},
  number       = {3},
  pages        = {221--226},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Chlorhexidine for prevention of neonatal colonization with group B streptococci. V. Chlorhexidine concentrations in blood following vaginal washing during delivery},
  url          = {http://dx.doi.org/10.1016/0028-2243(89)90156-1},
  volume       = {31},
  year         = {1989},
}