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Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia

Donnér, M; Békássy, Albert LU ; Heldrup, Jesper LU ; Wiebe, Thomas LU ; Garwicz, Stanislaw LU and Holmberg, Lars LU (1990) In Acta Paediatrica Scandinavica 79(3). p.328-334
Abstract
Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few... (More)
Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface-bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet-specific IgG in plasma was less sensitive (46%) but highly specific for immune-thrombocytopenia (89%). The measurements of platelet-surface-bound IgG and platelet-specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following the treatment in chronic ITP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thrombocytopenia, immune thrombocytopenia, childhood, platelet
in
Acta Paediatrica Scandinavica
volume
79
issue
3
pages
328 - 334
publisher
Taylor & Francis
external identifiers
  • pmid:1692176
  • scopus:0025234014
ISSN
0001-656X
DOI
10.1111/j.1651-2227.1990.tb11465.x
language
English
LU publication?
yes
id
10375b24-6b33-4b1f-8f72-916a6805a55b (old id 1104970)
date added to LUP
2008-08-04 14:38:58
date last changed
2017-01-01 07:18:07
@article{10375b24-6b33-4b1f-8f72-916a6805a55b,
  abstract     = {Quantification of platelet-bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand-binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune-thrombocytopenia from thrombocytopenia of non-immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet-surface bound IgG. The test was highly sensitive (93%) in detecting immune-thrombocytopenia. The specificity, however, was only 57%, which is less than in published studies of adults. In a number of cases presumed to be non-immune-thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface-bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet-specific IgG in plasma was less sensitive (46%) but highly specific for immune-thrombocytopenia (89%). The measurements of platelet-surface-bound IgG and platelet-specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following the treatment in chronic ITP.},
  author       = {Donnér, M and Békássy, Albert and Heldrup, Jesper and Wiebe, Thomas and Garwicz, Stanislaw and Holmberg, Lars},
  issn         = {0001-656X},
  keyword      = {thrombocytopenia,immune thrombocytopenia,childhood,platelet},
  language     = {eng},
  number       = {3},
  pages        = {328--334},
  publisher    = {Taylor & Francis},
  series       = {Acta Paediatrica Scandinavica},
  title        = {Platelet surface-bound IgG and platelet-specific IgG in plasma in childhood thrombocytopenia},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.1990.tb11465.x},
  volume       = {79},
  year         = {1990},
}