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Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells

Békássy, Albert LU ; Liliemark, Jan; Garwicz, Stanislaw LU ; Wiebe, Thomas LU ; Gulliksson, Hans and Peterson, Curt (1990) In Medical and Pediatric Oncology 18(2). p.136-142
Abstract
Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration... (More)
Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intrathecal, intraventricular, child, acute leukemia, CNS Leukemia
in
Medical and Pediatric Oncology
volume
18
issue
2
pages
136 - 142
publisher
John Wiley & Sons
external identifiers
  • pmid:2304422
  • scopus:0025219695
ISSN
1096-911X
DOI
10.1002/mpo.2950180210
language
English
LU publication?
yes
id
78e36588-7a70-4381-83c3-724942f946a5 (old id 1104976)
date added to LUP
2008-08-04 14:41:10
date last changed
2017-01-01 04:27:45
@article{78e36588-7a70-4381-83c3-724942f946a5,
  abstract     = {Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis.},
  author       = {Békássy, Albert and Liliemark, Jan and Garwicz, Stanislaw and Wiebe, Thomas and Gulliksson, Hans and Peterson, Curt},
  issn         = {1096-911X},
  keyword      = {intrathecal,intraventricular,child,acute leukemia,CNS Leukemia},
  language     = {eng},
  number       = {2},
  pages        = {136--142},
  publisher    = {John Wiley & Sons},
  series       = {Medical and Pediatric Oncology},
  title        = {Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells},
  url          = {http://dx.doi.org/10.1002/mpo.2950180210},
  volume       = {18},
  year         = {1990},
}