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Arterial rupture after microwave-induced hyperthermia and radiotherapy. With reference to two patients treated for recurrence in previously operated and irradiated areas

Lindholm, C E; Andreasson, L; Knöös, Tommy LU ; Landberg, Torsten LU and Ljungberg, Otto LU (1990) In International Journal of Hyperthermia 6(3). p.499-509
Abstract
Two patients who developed frank arterial bleeding after combined microwave-induced hyperthermia and radiotherapy are described. One patient received re-irradiation and hyperthermia for recurrent metastatic neck nodes of a mesopharyngeal carcinoma. Full course radiotherapy had been given 6 years previously and a right-sided radical neck node dissection had been performed 4 months earlier because of recurrent neck node metastases. Six weeks after the combined therapy for a second recurrence, which achieved complete remission, a fatal rupture of the carotid artery occurred. The other patient received re-irradiation and hyperthermia for a chest wall recurrence of a breast carcinoma, treated 5.5 years previously by sector resection and... (More)
Two patients who developed frank arterial bleeding after combined microwave-induced hyperthermia and radiotherapy are described. One patient received re-irradiation and hyperthermia for recurrent metastatic neck nodes of a mesopharyngeal carcinoma. Full course radiotherapy had been given 6 years previously and a right-sided radical neck node dissection had been performed 4 months earlier because of recurrent neck node metastases. Six weeks after the combined therapy for a second recurrence, which achieved complete remission, a fatal rupture of the carotid artery occurred. The other patient received re-irradiation and hyperthermia for a chest wall recurrence of a breast carcinoma, treated 5.5 years previously by sector resection and tangential beam radiotherapy, and treated again 2 years earlier with extensive surgery for a local recurrence. A frank arterial bleeding from the treated region was seen after 7 months, but could be arrested with surgery. This important complication in combined hyperthermia and radiotherapy does not seem to have been recognized before. Different explanations are discussed, such as the previous local treatment as well as high temperature and atherosclerosis per se. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial rupture, hyperthermia, complications
in
International Journal of Hyperthermia
volume
6
issue
3
pages
499 - 509
publisher
Taylor & Francis
external identifiers
  • pmid:2165509
  • scopus:0025332760
ISSN
0265-6736
DOI
10.3109/02656739009140946
language
English
LU publication?
yes
id
e805390a-0245-465d-a3b7-d12874564d1b (old id 1105063)
date added to LUP
2008-08-04 16:09:38
date last changed
2017-01-01 04:19:36
@article{e805390a-0245-465d-a3b7-d12874564d1b,
  abstract     = {Two patients who developed frank arterial bleeding after combined microwave-induced hyperthermia and radiotherapy are described. One patient received re-irradiation and hyperthermia for recurrent metastatic neck nodes of a mesopharyngeal carcinoma. Full course radiotherapy had been given 6 years previously and a right-sided radical neck node dissection had been performed 4 months earlier because of recurrent neck node metastases. Six weeks after the combined therapy for a second recurrence, which achieved complete remission, a fatal rupture of the carotid artery occurred. The other patient received re-irradiation and hyperthermia for a chest wall recurrence of a breast carcinoma, treated 5.5 years previously by sector resection and tangential beam radiotherapy, and treated again 2 years earlier with extensive surgery for a local recurrence. A frank arterial bleeding from the treated region was seen after 7 months, but could be arrested with surgery. This important complication in combined hyperthermia and radiotherapy does not seem to have been recognized before. Different explanations are discussed, such as the previous local treatment as well as high temperature and atherosclerosis per se.},
  author       = {Lindholm, C E and Andreasson, L and Knöös, Tommy and Landberg, Torsten and Ljungberg, Otto},
  issn         = {0265-6736},
  keyword      = {arterial rupture,hyperthermia,complications},
  language     = {eng},
  number       = {3},
  pages        = {499--509},
  publisher    = {Taylor & Francis},
  series       = {International Journal of Hyperthermia},
  title        = {Arterial rupture after microwave-induced hyperthermia and radiotherapy. With reference to two patients treated for recurrence in previously operated and irradiated areas},
  url          = {http://dx.doi.org/10.3109/02656739009140946},
  volume       = {6},
  year         = {1990},
}