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Mineral fibres, fibrosis, and asbestos bodies in lung tissue from deceased asbestos cement workers

Albin, Maria LU ; Johansson, Leif LU ; Pooley, F D; Jakobsson, Kristina LU ; Attewell, R and Mitha, R (1990) In British Journal of Industrial Medicine 47(11). p.767-774
Abstract
Lung tissue from 76 deceased asbestos cement workers (seven with mesothelioma) exposed to chrysotile asbestos and small amounts of amphiboles, has been studied by transmission electron microscopy, together with lung tissue from 96 controls. The exposed workers with mesothelioma had a significantly higher total content of asbestos fibre in the lungs than those without mesothelioma, who in turn, had higher concentrations than the controls (medians 189, 50, and 29 x 10(6) fibres/g (f/g]. Chrysotile was the major type of fibre. The differences were most pronounced for the amphibole fibres (62, 4.7, and 0.15 f/g), especially crocidolite (54, 1.8 and less than 0.001 f/g), but were evident also for tremolite (2.9, less than 0.001, and less than... (More)
Lung tissue from 76 deceased asbestos cement workers (seven with mesothelioma) exposed to chrysotile asbestos and small amounts of amphiboles, has been studied by transmission electron microscopy, together with lung tissue from 96 controls. The exposed workers with mesothelioma had a significantly higher total content of asbestos fibre in the lungs than those without mesothelioma, who in turn, had higher concentrations than the controls (medians 189, 50, and 29 x 10(6) fibres/g (f/g]. Chrysotile was the major type of fibre. The differences were most pronounced for the amphibole fibres (62, 4.7, and 0.15 f/g), especially crocidolite (54, 1.8 and less than 0.001 f/g), but were evident also for tremolite (2.9, less than 0.001, and less than 0.001 f/g) and anthophyllite (1.7, less than 0.001, and less than 0.001 f/g). For amosite, there was no statistically significant difference between lungs from workers with and without mesothelioma; the lungs of workers had, however, higher concentrations than the controls. Strong correlations were found between duration of exposure and content of amphibole fibres in the lungs. Asbestos bodies, counted by light microscopy, were significantly correlated with the amphibole but not with the chrysotile contents. Fibrosis was correlated with the tremolite but not the chrysotile content in lungs from both exposed workers and controls. Overall, similar results were obtained using fibre counts and estimates of mass. (Less)
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published
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in
British Journal of Industrial Medicine
volume
47
issue
11
pages
767 - 774
publisher
BMJ Publishing Group
external identifiers
  • pmid:2173948
  • scopus:0025095922
ISSN
0007-1072
language
English
LU publication?
yes
id
41cb6acc-8e77-4a28-a551-686e4fa84720 (old id 1105095)
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http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2173948
date added to LUP
2008-08-04 16:38:32
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2017-10-22 04:45:50
@article{41cb6acc-8e77-4a28-a551-686e4fa84720,
  abstract     = {Lung tissue from 76 deceased asbestos cement workers (seven with mesothelioma) exposed to chrysotile asbestos and small amounts of amphiboles, has been studied by transmission electron microscopy, together with lung tissue from 96 controls. The exposed workers with mesothelioma had a significantly higher total content of asbestos fibre in the lungs than those without mesothelioma, who in turn, had higher concentrations than the controls (medians 189, 50, and 29 x 10(6) fibres/g (f/g]. Chrysotile was the major type of fibre. The differences were most pronounced for the amphibole fibres (62, 4.7, and 0.15 f/g), especially crocidolite (54, 1.8 and less than 0.001 f/g), but were evident also for tremolite (2.9, less than 0.001, and less than 0.001 f/g) and anthophyllite (1.7, less than 0.001, and less than 0.001 f/g). For amosite, there was no statistically significant difference between lungs from workers with and without mesothelioma; the lungs of workers had, however, higher concentrations than the controls. Strong correlations were found between duration of exposure and content of amphibole fibres in the lungs. Asbestos bodies, counted by light microscopy, were significantly correlated with the amphibole but not with the chrysotile contents. Fibrosis was correlated with the tremolite but not the chrysotile content in lungs from both exposed workers and controls. Overall, similar results were obtained using fibre counts and estimates of mass.},
  author       = {Albin, Maria and Johansson, Leif and Pooley, F D and Jakobsson, Kristina and Attewell, R and Mitha, R},
  issn         = {0007-1072},
  language     = {eng},
  number       = {11},
  pages        = {767--774},
  publisher    = {BMJ Publishing Group},
  series       = {British Journal of Industrial Medicine},
  title        = {Mineral fibres, fibrosis, and asbestos bodies in lung tissue from deceased asbestos cement workers},
  volume       = {47},
  year         = {1990},
}