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Mortality and cancer morbidity in cohorts of asbestos cement workers and referents

Albin, Maria LU ; Jakobsson, Kristina LU ; Attewell, R; Johansson, Leif LU and Welinder, Hans LU (1990) In British Journal of Industrial Medicine 47(9). p.602-610
Abstract
Total and cause specific mortality and cancer morbidity were studied among 1929 asbestos cement workers with an estimated median cumulative exposure of 2.3 fibre (f)-years/ml (median intensity 1.2 f/ml, predominantly chrysotile). A local reference cohort of 1233 industrial workers and non-case referents from the exposed cohort were used for comparisons. The risk for pleural mesothelioma was significantly increased (13 cases out of 592 deaths in workers with at least 20 years latency). No case of peritoneal mesothelioma was found. A significant dose response relation was found for cumulative exposure 40 years or more before the diagnosis, with a multiplicative relative risk (RR) of 1.9 for each f-year/ml. No relation was found with duration... (More)
Total and cause specific mortality and cancer morbidity were studied among 1929 asbestos cement workers with an estimated median cumulative exposure of 2.3 fibre (f)-years/ml (median intensity 1.2 f/ml, predominantly chrysotile). A local reference cohort of 1233 industrial workers and non-case referents from the exposed cohort were used for comparisons. The risk for pleural mesothelioma was significantly increased (13 cases out of 592 deaths in workers with at least 20 years latency). No case of peritoneal mesothelioma was found. A significant dose response relation was found for cumulative exposure 40 years or more before the diagnosis, with a multiplicative relative risk (RR) of 1.9 for each f-year/ml. No relation was found with duration of exposure when latency was accounted for. There was a significant overrisk in non-malignant respiratory disease (RR = 2.6). The overall risks for respiratory cancer, excluding mesothelioma, and for gastrointestinal cancer were not significantly increased. Surprisingly, colorectal cancer displayed a clear relation with cumulative dose, with an estimated increase of 1.6% in the incidence density ratio for each f-year/ml (but not with duration of exposure). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Industrial Medicine
volume
47
issue
9
pages
602 - 610
publisher
BMJ Publishing Group
external identifiers
  • pmid:2207031
  • scopus:0025035687
ISSN
0007-1072
language
English
LU publication?
yes
id
16d30980-402b-4bed-bb88-23432471f2f4 (old id 1105101)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1035245&blobtype=pdf
date added to LUP
2008-08-04 16:41:28
date last changed
2017-07-09 04:14:10
@article{16d30980-402b-4bed-bb88-23432471f2f4,
  abstract     = {Total and cause specific mortality and cancer morbidity were studied among 1929 asbestos cement workers with an estimated median cumulative exposure of 2.3 fibre (f)-years/ml (median intensity 1.2 f/ml, predominantly chrysotile). A local reference cohort of 1233 industrial workers and non-case referents from the exposed cohort were used for comparisons. The risk for pleural mesothelioma was significantly increased (13 cases out of 592 deaths in workers with at least 20 years latency). No case of peritoneal mesothelioma was found. A significant dose response relation was found for cumulative exposure 40 years or more before the diagnosis, with a multiplicative relative risk (RR) of 1.9 for each f-year/ml. No relation was found with duration of exposure when latency was accounted for. There was a significant overrisk in non-malignant respiratory disease (RR = 2.6). The overall risks for respiratory cancer, excluding mesothelioma, and for gastrointestinal cancer were not significantly increased. Surprisingly, colorectal cancer displayed a clear relation with cumulative dose, with an estimated increase of 1.6% in the incidence density ratio for each f-year/ml (but not with duration of exposure).},
  author       = {Albin, Maria and Jakobsson, Kristina and Attewell, R and Johansson, Leif and Welinder, Hans},
  issn         = {0007-1072},
  language     = {eng},
  number       = {9},
  pages        = {602--610},
  publisher    = {BMJ Publishing Group},
  series       = {British Journal of Industrial Medicine},
  title        = {Mortality and cancer morbidity in cohorts of asbestos cement workers and referents},
  volume       = {47},
  year         = {1990},
}