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Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in type 1 (insulin-dependent) diabetes mellitus and in normal man

Tallroth, G; Lindgren, Magnus LU ; Stenberg, Georg LU ; Rosén, Ingmar LU and Agardh, Carl-David LU (1990) In Diabetologia 33(5). p.319-323
Abstract
Hypoglycaemia (median venous blood glucose 1.8 mmol/l; range 1.6-2.3) was induced by an intravenous infusion of regular insulin in eight patients with Type 1 (insulin-dependent) diabetes mellitus (age 28.0 +/- 7.4 years; mean +/- SD, duration 15.5 +/- 5.1 years) and in 12 age-matched healthy male control subjects. Multi-channel frequency analysis of electroencephalogram (electrophysiologic brain mapping) and recording of P300 and somatosensory evoked potentials were performed before, during and immediately after the hypoglycaemic period. The hypoglycaemia produced a significant increase in low frequency electroencephalographic activity in both groups, most pronounced over anterior regions of the brain. The electroencephalographic activity... (More)
Hypoglycaemia (median venous blood glucose 1.8 mmol/l; range 1.6-2.3) was induced by an intravenous infusion of regular insulin in eight patients with Type 1 (insulin-dependent) diabetes mellitus (age 28.0 +/- 7.4 years; mean +/- SD, duration 15.5 +/- 5.1 years) and in 12 age-matched healthy male control subjects. Multi-channel frequency analysis of electroencephalogram (electrophysiologic brain mapping) and recording of P300 and somatosensory evoked potentials were performed before, during and immediately after the hypoglycaemic period. The hypoglycaemia produced a significant increase in low frequency electroencephalographic activity in both groups, most pronounced over anterior regions of the brain. The electroencephalographic activity was normalised immediately after the hypoglycaemic period. The patients with diabetes showed somewhat longer P300 latencies during the initial normoglycaemic examination. Hypoglycaemia caused a marked reduction of the P300 amplitude in both groups of subjects and the amplitude was not restored immediately after normalisation of blood glucose levels. The somatosensory cortical responses were not affected by hypoglycaemia. We conclude that hypoglycaemia results in impairment in cerebral function, as measured by neurophysiological techniques, which is not immediately normalised when blood glucose is restored to normal. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Electroencephalogram, P300, somatosensory evoked response, hypoglycaemia, diabetes mellitus
in
Diabetologia
volume
33
issue
5
pages
319 - 323
publisher
Springer Verlag
external identifiers
  • pmid:2198189
  • scopus:0025342391
ISSN
1432-0428
DOI
10.1007/BF00403327
language
English
LU publication?
yes
id
b0f1cd22-275c-4648-9849-c508807db37d (old id 1105111)
date added to LUP
2008-08-04 16:59:26
date last changed
2017-05-07 03:36:58
@article{b0f1cd22-275c-4648-9849-c508807db37d,
  abstract     = {Hypoglycaemia (median venous blood glucose 1.8 mmol/l; range 1.6-2.3) was induced by an intravenous infusion of regular insulin in eight patients with Type 1 (insulin-dependent) diabetes mellitus (age 28.0 +/- 7.4 years; mean +/- SD, duration 15.5 +/- 5.1 years) and in 12 age-matched healthy male control subjects. Multi-channel frequency analysis of electroencephalogram (electrophysiologic brain mapping) and recording of P300 and somatosensory evoked potentials were performed before, during and immediately after the hypoglycaemic period. The hypoglycaemia produced a significant increase in low frequency electroencephalographic activity in both groups, most pronounced over anterior regions of the brain. The electroencephalographic activity was normalised immediately after the hypoglycaemic period. The patients with diabetes showed somewhat longer P300 latencies during the initial normoglycaemic examination. Hypoglycaemia caused a marked reduction of the P300 amplitude in both groups of subjects and the amplitude was not restored immediately after normalisation of blood glucose levels. The somatosensory cortical responses were not affected by hypoglycaemia. We conclude that hypoglycaemia results in impairment in cerebral function, as measured by neurophysiological techniques, which is not immediately normalised when blood glucose is restored to normal.},
  author       = {Tallroth, G and Lindgren, Magnus and Stenberg, Georg and Rosén, Ingmar and Agardh, Carl-David},
  issn         = {1432-0428},
  keyword      = {Electroencephalogram,P300,somatosensory evoked response,hypoglycaemia,diabetes mellitus},
  language     = {eng},
  number       = {5},
  pages        = {319--323},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in type 1 (insulin-dependent) diabetes mellitus and in normal man},
  url          = {http://dx.doi.org/10.1007/BF00403327},
  volume       = {33},
  year         = {1990},
}