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A long-term prospective study of optic neuritis: evaluation of risk factors

Sandberg Wollheim, Magnhild LU ; Bynke, Hans LU ; Cronqvist, Sten; Holtås, Stig LU ; Platz, Per and Ryder, Lars P (1990) In Annals of Neurology 27(4). p.386-393
Abstract
Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not... (More)
Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not significantly. Magnetic resonance imaging detected bilateral discrete white matter lesions, similar to those in MS, in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Neurology
volume
27
issue
4
pages
386 - 393
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:2353793
  • scopus:0025271721
ISSN
1531-8249
DOI
10.1002/ana.410270406
language
English
LU publication?
yes
id
6618945a-67c4-47a3-aec2-867c505bf4a3 (old id 1105216)
date added to LUP
2008-08-05 11:07:26
date last changed
2017-08-06 03:34:49
@article{6618945a-67c4-47a3-aec2-867c505bf4a3,
  abstract     = {Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not significantly. Magnetic resonance imaging detected bilateral discrete white matter lesions, similar to those in MS, in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS.},
  author       = {Sandberg Wollheim, Magnhild and Bynke, Hans and Cronqvist, Sten and Holtås, Stig and Platz, Per and Ryder, Lars P},
  issn         = {1531-8249},
  language     = {eng},
  number       = {4},
  pages        = {386--393},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Annals of Neurology},
  title        = {A long-term prospective study of optic neuritis: evaluation of risk factors},
  url          = {http://dx.doi.org/10.1002/ana.410270406},
  volume       = {27},
  year         = {1990},
}