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The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

Nilsson, Christer LU ; Kannisto, Päivi LU ; Lindvall-Axelsson, Maria; Owman, Christer LU and Rosengren, Evald LU (1990) In European Journal of Pharmacology 181(3). p.247-252
Abstract
The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%,... (More)
The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Presynaptic regulation, Sympathetic nerves, Choroid plexus, VIP (vasoactive intestinal polypeptide), PHI (peptide histidine isoleucine), Neuropeptide Y
in
European Journal of Pharmacology
volume
181
issue
3
pages
247 - 252
publisher
Elsevier
external identifiers
  • pmid:2384133
  • scopus:0025347936
ISSN
1879-0712
DOI
10.1016/0014-2999(90)90085-K
language
English
LU publication?
yes
id
5b1168aa-9fc5-4c0a-8695-6013f636c2a6 (old id 1105331)
date added to LUP
2008-08-05 12:41:56
date last changed
2017-07-30 03:49:41
@article{5b1168aa-9fc5-4c0a-8695-6013f636c2a6,
  abstract     = {The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.},
  author       = {Nilsson, Christer and Kannisto, Päivi and Lindvall-Axelsson, Maria and Owman, Christer and Rosengren, Evald},
  issn         = {1879-0712},
  keyword      = {Presynaptic regulation,Sympathetic nerves,Choroid plexus,VIP (vasoactive intestinal polypeptide),PHI (peptide histidine isoleucine),Neuropeptide Y},
  language     = {eng},
  number       = {3},
  pages        = {247--252},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus},
  url          = {http://dx.doi.org/10.1016/0014-2999(90)90085-K},
  volume       = {181},
  year         = {1990},
}