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Adrenoceptors mediating contraction in the human uterine artery

Stjernquist, Martin LU and Owman, Christer LU (1990) In Human Reproduction 5(1). p.19-24
Abstract
Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist,... (More)
Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the alpha 2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the alpha 1 type, and give no evidence for any substantial involvement of alpha 2-receptors in this important tributary vessel of the human female reproductive tract. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle
in
Human Reproduction
volume
5
issue
1
pages
19 - 24
publisher
Oxford University Press
external identifiers
  • pmid:2324242
  • scopus:0025319271
ISSN
0268-1161
language
English
LU publication?
yes
id
4307ab09-d758-4837-bed0-5f0ef177088a (old id 1105370)
alternative location
http://humrep.oxfordjournals.org/cgi/reprint/5/1/19
date added to LUP
2008-08-05 13:07:08
date last changed
2017-08-06 03:40:07
@article{4307ab09-d758-4837-bed0-5f0ef177088a,
  abstract     = {Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the alpha 2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the alpha 1 type, and give no evidence for any substantial involvement of alpha 2-receptors in this important tributary vessel of the human female reproductive tract.},
  author       = {Stjernquist, Martin and Owman, Christer},
  issn         = {0268-1161},
  keyword      = {adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle},
  language     = {eng},
  number       = {1},
  pages        = {19--24},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Adrenoceptors mediating contraction in the human uterine artery},
  volume       = {5},
  year         = {1990},
}