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Three RFLP's at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland

Palsdottir, A; Jonsdottir, S; Abrahamson, Magnus LU ; Grubb, Anders LU and Jensson, O (1990) In Nucleic Acids Research 18(24). p.7471-7471
Abstract
Sputum samples from 25 patients with bronchiectasis were assayed enzymatically for myeloperoxidase, neutrophil elastase and cathepsin B, and immunologically for cystatin A, cystatin B, cystatin C, cystatin S and kininogen. High myeloperoxidase and neutrophil elastase levels were found in those sputum samples that were assessed visually to be purulent. These samples were also found to contain high levels of cathepsin B activity and cystatin A, but low levels of cystatin S and of the most effective cathepsin B inhibitor, cystatin C. In contrast, sputum samples that were low in myeloperoxidase and neutrophil elastase activities had low levels of cathepsin B and cystatin A, but high cystatin C and S levels. It is concluded that cathepsin B... (More)
Sputum samples from 25 patients with bronchiectasis were assayed enzymatically for myeloperoxidase, neutrophil elastase and cathepsin B, and immunologically for cystatin A, cystatin B, cystatin C, cystatin S and kininogen. High myeloperoxidase and neutrophil elastase levels were found in those sputum samples that were assessed visually to be purulent. These samples were also found to contain high levels of cathepsin B activity and cystatin A, but low levels of cystatin S and of the most effective cathepsin B inhibitor, cystatin C. In contrast, sputum samples that were low in myeloperoxidase and neutrophil elastase activities had low levels of cathepsin B and cystatin A, but high cystatin C and S levels. It is concluded that cathepsin B activity in sputum is positively correlated with the degree of inflammation and neutrophil recruitment. Although this may be due in part to reduced amounts of cathepsin B inhibitors, particularly cystatin C, theoretical considerations suggest that factors other than the gross level of inhibitors must be involved in the control of cathepsin B activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic Acids Research
volume
18
issue
24
pages
7471 - 7471
publisher
Oxford University Press
external identifiers
  • pmid:1979681
  • scopus:0025603140
ISSN
1362-4962
DOI
10.1093/nar/18.24.7471-a
language
English
LU publication?
yes
id
d35559fa-5a6f-4f90-acd2-6867ef0823e8 (old id 1105573)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=332913&blobtype=pdf
date added to LUP
2008-08-06 08:32:42
date last changed
2017-01-01 04:44:04
@article{d35559fa-5a6f-4f90-acd2-6867ef0823e8,
  abstract     = {Sputum samples from 25 patients with bronchiectasis were assayed enzymatically for myeloperoxidase, neutrophil elastase and cathepsin B, and immunologically for cystatin A, cystatin B, cystatin C, cystatin S and kininogen. High myeloperoxidase and neutrophil elastase levels were found in those sputum samples that were assessed visually to be purulent. These samples were also found to contain high levels of cathepsin B activity and cystatin A, but low levels of cystatin S and of the most effective cathepsin B inhibitor, cystatin C. In contrast, sputum samples that were low in myeloperoxidase and neutrophil elastase activities had low levels of cathepsin B and cystatin A, but high cystatin C and S levels. It is concluded that cathepsin B activity in sputum is positively correlated with the degree of inflammation and neutrophil recruitment. Although this may be due in part to reduced amounts of cathepsin B inhibitors, particularly cystatin C, theoretical considerations suggest that factors other than the gross level of inhibitors must be involved in the control of cathepsin B activity.},
  author       = {Palsdottir, A and Jonsdottir, S and Abrahamson, Magnus and Grubb, Anders and Jensson, O},
  issn         = {1362-4962},
  language     = {eng},
  number       = {24},
  pages        = {7471--7471},
  publisher    = {Oxford University Press},
  series       = {Nucleic Acids Research},
  title        = {Three RFLP's at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland},
  url          = {http://dx.doi.org/10.1093/nar/18.24.7471-a},
  volume       = {18},
  year         = {1990},
}