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Reversible changes on computed tomography scans of the brain during induction therapy for acute lymphoblastic leukemia in children

Wiebe, Thomas LU ; Cronqvist, S; Békássy, Albert LU and Garwicz, Stanislaw LU (1991) In Pediatric Hematology & Oncology 8(3). p.257-262
Abstract
Children with acute lymphoblastic leukemia (ALL) have been shown to develop changes on computed tomography (CT) scans of the brain. These changes are seen both during and after therapy. Some of the results have been contradictory. Nine children with ALL were examined by CT of the brain during induction therapy. All children showed normal CT scans on the day of diagnosis. One month later all had dilatation of the ventricles and widened sulci. During the next 9 months the CT scans gradually were normalized. We conclude that such changes in CT scans of the brain are transitory and are caused by the high dose of prednisolone administered during induction therapy.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prednisolone, reversible, acute leukemia, brain, CT scan, children
in
Pediatric Hematology & Oncology
volume
8
issue
3
pages
257 - 262
publisher
Hemisphere Pub. Corp.
external identifiers
  • pmid:1742185
  • scopus:0026080070
ISSN
1521-0669
DOI
10.3109/08880019109033460
language
English
LU publication?
yes
id
2298fd1f-3243-49ef-89e9-1cc95a996363 (old id 1105634)
date added to LUP
2008-08-01 15:06:24
date last changed
2017-01-01 04:40:03
@article{2298fd1f-3243-49ef-89e9-1cc95a996363,
  abstract     = {Children with acute lymphoblastic leukemia (ALL) have been shown to develop changes on computed tomography (CT) scans of the brain. These changes are seen both during and after therapy. Some of the results have been contradictory. Nine children with ALL were examined by CT of the brain during induction therapy. All children showed normal CT scans on the day of diagnosis. One month later all had dilatation of the ventricles and widened sulci. During the next 9 months the CT scans gradually were normalized. We conclude that such changes in CT scans of the brain are transitory and are caused by the high dose of prednisolone administered during induction therapy.},
  author       = {Wiebe, Thomas and Cronqvist, S and Békássy, Albert and Garwicz, Stanislaw},
  issn         = {1521-0669},
  keyword      = {prednisolone,reversible,acute leukemia,brain,CT scan,children},
  language     = {eng},
  number       = {3},
  pages        = {257--262},
  publisher    = {Hemisphere Pub. Corp.},
  series       = {Pediatric Hematology & Oncology},
  title        = {Reversible changes on computed tomography scans of the brain during induction therapy for acute lymphoblastic leukemia in children},
  url          = {http://dx.doi.org/10.3109/08880019109033460},
  volume       = {8},
  year         = {1991},
}