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Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions

Olsson, Håkan LU ; Ranstam, J; Baldetorp, Bo LU ; Ewers, Sven-Börje LU ; Fernö, Mårten LU ; Killander, Dick LU and Sigurdsson, H (1991) In Cancer 67(5). p.1285-1290
Abstract
In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P = 0.05 and p = 0.01, respectively). The higher SPF among early OC users was apparent in patients with aneuploid tumors but not in patients with euploid tumors. Abortions (spontaneous or induced) before the first full-term pregnancy also were associated with a higher SPF compared with other young patients with breast cancer (P = 0.03). Adjusting for parity and abortions or OC use, respectively, an early OC use was associated... (More)
In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P = 0.05 and p = 0.01, respectively). The higher SPF among early OC users was apparent in patients with aneuploid tumors but not in patients with euploid tumors. Abortions (spontaneous or induced) before the first full-term pregnancy also were associated with a higher SPF compared with other young patients with breast cancer (P = 0.03). Adjusting for parity and abortions or OC use, respectively, an early OC use was associated with a 43% higher SPF and early abortions were associated with 49% higher SPF. Younger patients had a higher SPF and a higher frequency of aneuploid tumors, but this was found to be because the users of OC had a lower median age at diagnosis. Among never users, no significant age relationship was seen for SPF or the frequency of aneuploidy. For the DNA analyses there is a selection of patients with breast cancer with larger tumors, and therefore the conclusions drawn in this article may not be generalizable to patients with smaller primary tumors, e.g., cases diagnosed at breast cancer screening. The higher tumor proliferative activity and frequency of aneuploidy in early OC users are in line with previously reported findings of worse prognostic indicators and a worse survival in early users of OC compared with other young women with breast cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer
volume
67
issue
5
pages
1285 - 1290
publisher
John Wiley & Sons
external identifiers
  • pmid:1991290
  • scopus:0025963518
ISSN
1097-0142
DOI
10.1002/1097-0142(19910301)67:5<1285::AID-CNCR2820670502>3.0.CO;2-Q
language
English
LU publication?
yes
id
85255477-dac8-4c37-819c-9e98223f8a48 (old id 1105658)
date added to LUP
2008-08-04 09:33:47
date last changed
2017-05-07 03:41:12
@article{85255477-dac8-4c37-819c-9e98223f8a48,
  abstract     = {In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P = 0.05 and p = 0.01, respectively). The higher SPF among early OC users was apparent in patients with aneuploid tumors but not in patients with euploid tumors. Abortions (spontaneous or induced) before the first full-term pregnancy also were associated with a higher SPF compared with other young patients with breast cancer (P = 0.03). Adjusting for parity and abortions or OC use, respectively, an early OC use was associated with a 43% higher SPF and early abortions were associated with 49% higher SPF. Younger patients had a higher SPF and a higher frequency of aneuploid tumors, but this was found to be because the users of OC had a lower median age at diagnosis. Among never users, no significant age relationship was seen for SPF or the frequency of aneuploidy. For the DNA analyses there is a selection of patients with breast cancer with larger tumors, and therefore the conclusions drawn in this article may not be generalizable to patients with smaller primary tumors, e.g., cases diagnosed at breast cancer screening. The higher tumor proliferative activity and frequency of aneuploidy in early OC users are in line with previously reported findings of worse prognostic indicators and a worse survival in early users of OC compared with other young women with breast cancer.},
  author       = {Olsson, Håkan and Ranstam, J and Baldetorp, Bo and Ewers, Sven-Börje and Fernö, Mårten and Killander, Dick and Sigurdsson, H},
  issn         = {1097-0142},
  language     = {eng},
  number       = {5},
  pages        = {1285--1290},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions},
  url          = {http://dx.doi.org/10.1002/1097-0142(19910301)67:5<1285::AID-CNCR2820670502>3.0.CO;2-Q},
  volume       = {67},
  year         = {1991},
}