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Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride

Jönsson, Bo A LU ; Welinder, Hans LU and Skarping, Gunnar LU (1991) In International Archives of Occupational and Environmental Health 63(1). p.77-79
Abstract
Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were less than 0.04-0.3 mumol HHP acid/mmol creatinine. In unexposed controls, the level was less than 0.1 mumol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (rs = 0.93; P less than 0.023), indicating that the determination of HHP acid in urine... (More)
Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were less than 0.04-0.3 mumol HHP acid/mmol creatinine. In unexposed controls, the level was less than 0.1 mumol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (rs = 0.93; P less than 0.023), indicating that the determination of HHP acid in urine is suitable for biologic monitoring of HHPA exposure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epoxy resin, Hexahydrophthalic anhydride, Hexahydrophthalic acid, Urinary excretion, Biological monitoring
in
International Archives of Occupational and Environmental Health
volume
63
issue
1
pages
77 - 79
publisher
Springer
external identifiers
  • pmid:1856027
  • scopus:0025854439
ISSN
1432-1246
DOI
10.1007/BF00406202
language
English
LU publication?
yes
id
358e8ab0-8e7e-4f46-b81c-b75735126acb (old id 1105709)
date added to LUP
2008-08-04 10:06:33
date last changed
2017-01-01 07:20:20
@article{358e8ab0-8e7e-4f46-b81c-b75735126acb,
  abstract     = {Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were less than 0.04-0.3 mumol HHP acid/mmol creatinine. In unexposed controls, the level was less than 0.1 mumol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (rs = 0.93; P less than 0.023), indicating that the determination of HHP acid in urine is suitable for biologic monitoring of HHPA exposure.},
  author       = {Jönsson, Bo A and Welinder, Hans and Skarping, Gunnar},
  issn         = {1432-1246},
  keyword      = {Epoxy resin,Hexahydrophthalic anhydride,Hexahydrophthalic acid,Urinary excretion,Biological monitoring},
  language     = {eng},
  number       = {1},
  pages        = {77--79},
  publisher    = {Springer},
  series       = {International Archives of Occupational and Environmental Health},
  title        = {Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride},
  url          = {http://dx.doi.org/10.1007/BF00406202},
  volume       = {63},
  year         = {1991},
}