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Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.

Sitnicka Quinn, Ewa LU ; Bryder, David LU ; Theilgaard-Mönch, Kim; Buza-Vidas, Natalija LU ; Adolfsson, Jörgen LU and Jacobsen, Sten Eirik W LU (2002) In Immunity 17(4). p.463-472
Abstract
The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the... (More)
The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
17
issue
4
pages
463 - 472
publisher
Cell Press
external identifiers
  • pmid:12387740
  • wos:000178667100007
  • scopus:0036797682
ISSN
1074-7613
DOI
10.1016/S1074-7613(02)00419-3
language
English
LU publication?
yes
id
99c2b32e-f9cf-4afb-8052-6d71d776ad00 (old id 110578)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12387740&dopt=Abstract
date added to LUP
2007-07-24 09:38:17
date last changed
2017-09-24 03:35:52
@article{99c2b32e-f9cf-4afb-8052-6d71d776ad00,
  abstract     = {The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.},
  author       = {Sitnicka Quinn, Ewa and Bryder, David and Theilgaard-Mönch, Kim and Buza-Vidas, Natalija and Adolfsson, Jörgen and Jacobsen, Sten Eirik W},
  issn         = {1074-7613},
  language     = {eng},
  number       = {4},
  pages        = {463--472},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.},
  url          = {http://dx.doi.org/10.1016/S1074-7613(02)00419-3},
  volume       = {17},
  year         = {2002},
}