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Effects of drugs and electrical field stimulation on isolated muscle strips from rabbit pharyngoesophageal segment

Malmberg, Lars; Ekberg, Olle LU and Ekstrom, Jörgen (1991) In Dysphagia 6(4). p.203-208
Abstract
Muscle activity of isolated muscle strips from the middle pharyngeal constrictor, the inferior pharyngeal constrictor, the cricopharyngeal muscle, and the cervical esophagus of the rabbit was studied in organ baths in response to drugs and electrical field stimulation. These muscles of the pharyngoesophageal segment seem to lack an autonomic adrenergic and cholinergic innervation, as determined by responses to specific drugs. The nerve-evoked contractile responses of the two lower muscles of the segment were almost completely abolished by the curarelike drug gallamine, suggesting a somatic cholinergic nerve supply. However, in the two upper muscles, the major part of the response was resistant to gallamine, which suggests involvement of... (More)
Muscle activity of isolated muscle strips from the middle pharyngeal constrictor, the inferior pharyngeal constrictor, the cricopharyngeal muscle, and the cervical esophagus of the rabbit was studied in organ baths in response to drugs and electrical field stimulation. These muscles of the pharyngoesophageal segment seem to lack an autonomic adrenergic and cholinergic innervation, as determined by responses to specific drugs. The nerve-evoked contractile responses of the two lower muscles of the segment were almost completely abolished by the curarelike drug gallamine, suggesting a somatic cholinergic nerve supply. However, in the two upper muscles, the major part of the response was resistant to gallamine, which suggests involvement of non-adrenergic, nonmuscarinic, nonnicotinic receptors in the transmission of nerve impulses in these muscles. These results suggest a differential innervation of the upper and lower pharyngeal muscles. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pharyngoesophageal segment, Electrical stimulation, In vitro contractile responses, Cholinergic, adrenergic blockers, Deglutition, Deglutition disorders
in
Dysphagia
volume
6
issue
4
pages
203 - 208
publisher
Springer
external identifiers
  • pmid:1778096
  • scopus:0026323823
ISSN
1432-0460
DOI
10.1007/BF02493527
language
English
LU publication?
yes
id
e04cd542-4ef9-40f6-ba7c-81d244cc4ec5 (old id 1105858)
date added to LUP
2008-08-04 12:29:09
date last changed
2017-01-01 04:38:10
@article{e04cd542-4ef9-40f6-ba7c-81d244cc4ec5,
  abstract     = {Muscle activity of isolated muscle strips from the middle pharyngeal constrictor, the inferior pharyngeal constrictor, the cricopharyngeal muscle, and the cervical esophagus of the rabbit was studied in organ baths in response to drugs and electrical field stimulation. These muscles of the pharyngoesophageal segment seem to lack an autonomic adrenergic and cholinergic innervation, as determined by responses to specific drugs. The nerve-evoked contractile responses of the two lower muscles of the segment were almost completely abolished by the curarelike drug gallamine, suggesting a somatic cholinergic nerve supply. However, in the two upper muscles, the major part of the response was resistant to gallamine, which suggests involvement of non-adrenergic, nonmuscarinic, nonnicotinic receptors in the transmission of nerve impulses in these muscles. These results suggest a differential innervation of the upper and lower pharyngeal muscles.},
  author       = {Malmberg, Lars and Ekberg, Olle and Ekstrom, Jörgen},
  issn         = {1432-0460},
  keyword      = {Pharyngoesophageal segment,Electrical stimulation,In vitro contractile responses,Cholinergic,adrenergic blockers,Deglutition,Deglutition disorders},
  language     = {eng},
  number       = {4},
  pages        = {203--208},
  publisher    = {Springer},
  series       = {Dysphagia},
  title        = {Effects of drugs and electrical field stimulation on isolated muscle strips from rabbit pharyngoesophageal segment},
  url          = {http://dx.doi.org/10.1007/BF02493527},
  volume       = {6},
  year         = {1991},
}