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Attenuation and scatter correction in SPECT for sources in a nonhomogeneous object: a monte Carlo study

Ljungberg, Michael LU and Strand, Sven-Erik LU (1991) In Journal of Nuclear Medicine 32(6). p.1278-1284
Abstract
Single-photon emission computed tomography (SPECT) is important for imaging radioactivity distributions in vivo. Quantitative SPECT is limited due to attenuation and scatter contribution. Approximations such as constant attenuation and mono-exponential scatter functions will not be valid for non-homogeneous regions. A correction method is described where non-uniform density-maps are used in the attenuation correction. Correction for non-uniform scatter is made by a convolution technique based on scatter line-spread functions (SLSF) calculated for different locations inside a clinically realistic, nonhomogeneous, computer phantom. Calculations have been made for a myocardiac source, a uniform source in the lungs and a tumor located in the... (More)
Single-photon emission computed tomography (SPECT) is important for imaging radioactivity distributions in vivo. Quantitative SPECT is limited due to attenuation and scatter contribution. Approximations such as constant attenuation and mono-exponential scatter functions will not be valid for non-homogeneous regions. A correction method is described where non-uniform density-maps are used in the attenuation correction. Correction for non-uniform scatter is made by a convolution technique based on scatter line-spread functions (SLSF) calculated for different locations inside a clinically realistic, nonhomogeneous, computer phantom. Calculations have been made for a myocardiac source, a uniform source in the lungs and a tumor located in the lungs. Projections were simulated for photon energies corresponding to 201Tl, 99mTc, and 111In. The results show that quantitative images can be obtained in nonhomogeneous regions. An increased contrast has also been demonstrated in the SLSF-corrected images. Comparison with measurements have been made to validate the Monte Carlo code and the scatter and attenuation method. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
32
issue
6
pages
1278 - 1284
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:2045947
  • scopus:0025773696
ISSN
0161-5505
language
English
LU publication?
yes
id
cb6b9943-107e-41d4-b068-13e1a05d8d35 (old id 1105908)
alternative location
http://jnm.snmjournals.org/cgi/reprint/32/6/1278
date added to LUP
2008-08-01 14:03:02
date last changed
2017-08-06 04:42:27
@article{cb6b9943-107e-41d4-b068-13e1a05d8d35,
  abstract     = {Single-photon emission computed tomography (SPECT) is important for imaging radioactivity distributions in vivo. Quantitative SPECT is limited due to attenuation and scatter contribution. Approximations such as constant attenuation and mono-exponential scatter functions will not be valid for non-homogeneous regions. A correction method is described where non-uniform density-maps are used in the attenuation correction. Correction for non-uniform scatter is made by a convolution technique based on scatter line-spread functions (SLSF) calculated for different locations inside a clinically realistic, nonhomogeneous, computer phantom. Calculations have been made for a myocardiac source, a uniform source in the lungs and a tumor located in the lungs. Projections were simulated for photon energies corresponding to 201Tl, 99mTc, and 111In. The results show that quantitative images can be obtained in nonhomogeneous regions. An increased contrast has also been demonstrated in the SLSF-corrected images. Comparison with measurements have been made to validate the Monte Carlo code and the scatter and attenuation method.},
  author       = {Ljungberg, Michael and Strand, Sven-Erik},
  issn         = {0161-5505},
  language     = {eng},
  number       = {6},
  pages        = {1278--1284},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {Attenuation and scatter correction in SPECT for sources in a nonhomogeneous object: a monte Carlo study},
  volume       = {32},
  year         = {1991},
}