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Sensorimotor performance and rotation correlate to lesion size in right but not left hemisphere brain infarcts in the spontaneously hypertensive rat

Grabowski, Martin LU ; Nordborg, Claes and Johansson, Barbro LU (1991) In Brain Research 547(2). p.249-257
Abstract
In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size... (More)
In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size of the right hemisphere lesion was highly correlated to the total sensorimotor deficit. Furthermore, the sensorimotor deficit of specific body parts was found to correlate to the damage of certain brain regions in a rostrocaudal fashion, reminiscent of a somatotopical organization. The extent of ipsilateral rotation correlated to brain tissue loss at the level of the posterior caudate-putamen. The present results indicate an asymmetrical organization for brain functions involved in the performance of the rotation and sensorimotor tests. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Spontaneously hypertensive rat, Middle cerebral artery occlusion, Lesion size, Behavior, Brain lateralization
in
Brain Research
volume
547
issue
2
pages
249 - 257
publisher
Elsevier
external identifiers
  • pmid:1884199
  • scopus:0025854392
ISSN
1872-6240
DOI
10.1016/0006-8993(91)90968-2
language
English
LU publication?
yes
id
65f00dd1-22b9-4d16-8f02-87a39e2de2cb (old id 1105920)
date added to LUP
2008-08-04 14:05:06
date last changed
2017-04-23 03:39:18
@article{65f00dd1-22b9-4d16-8f02-87a39e2de2cb,
  abstract     = {In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size of the right hemisphere lesion was highly correlated to the total sensorimotor deficit. Furthermore, the sensorimotor deficit of specific body parts was found to correlate to the damage of certain brain regions in a rostrocaudal fashion, reminiscent of a somatotopical organization. The extent of ipsilateral rotation correlated to brain tissue loss at the level of the posterior caudate-putamen. The present results indicate an asymmetrical organization for brain functions involved in the performance of the rotation and sensorimotor tests.},
  author       = {Grabowski, Martin and Nordborg, Claes and Johansson, Barbro},
  issn         = {1872-6240},
  keyword      = {Spontaneously hypertensive rat,Middle cerebral artery occlusion,Lesion size,Behavior,Brain lateralization},
  language     = {eng},
  number       = {2},
  pages        = {249--257},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Sensorimotor performance and rotation correlate to lesion size in right but not left hemisphere brain infarcts in the spontaneously hypertensive rat},
  url          = {http://dx.doi.org/10.1016/0006-8993(91)90968-2},
  volume       = {547},
  year         = {1991},
}