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The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction

Nordborg, Claes; Sokrab, T E and Johansson, Barbro LU (1991) In Acta Neuropathologica 82(2). p.118-126
Abstract
Extravasated endogenous serum albumin and fibrinogen were identified immunohistochemically in coronal brain sections from normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) after permanent ligation of the right middle cerebral artery. Infarcts were seen in all the SHR but only in 6 out of 14 WKY. Six hours after ligation, extravasated proteins were located primarily within the borders of the infarcts whereas after 24 h and later there was an increasing spread in the white matter. After 7 days, a protein immunoreactivity was seen far outside the infarcted areas, mainly in the white matter and occasionally extending somewhat into the contralateral side. Three weeks after permanent ligation, the immunoreactivity... (More)
Extravasated endogenous serum albumin and fibrinogen were identified immunohistochemically in coronal brain sections from normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) after permanent ligation of the right middle cerebral artery. Infarcts were seen in all the SHR but only in 6 out of 14 WKY. Six hours after ligation, extravasated proteins were located primarily within the borders of the infarcts whereas after 24 h and later there was an increasing spread in the white matter. After 7 days, a protein immunoreactivity was seen far outside the infarcted areas, mainly in the white matter and occasionally extending somewhat into the contralateral side. Three weeks after permanent ligation, the immunoreactivity for plasma proteins had a similar extension but was less intense than after 7 days. A gliosis was noted within the protein-positive regions. From 72 h and onwards the immunoreactivity for albumin but not for fibrinogen extended via the white matter into the ipsilateral thalamic nuclei, where marked, mainly cytolytic nerve cell damage and gliosis was found. The close spatial correlation with albumin immunopositivity and the histological features of the thalamic lesions indicate that the propagation of extravasated plasma constituents or degradation products from the infarct may influence the character, timing and extent of remote tissue changes after cerebral infarction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain infarct, vasogenic edema, thalamus, neuron, degeneration
in
Acta Neuropathologica
volume
82
issue
2
pages
118 - 126
publisher
Springer
external identifiers
  • pmid:1927267
  • scopus:0025831833
ISSN
1432-0533
DOI
10.1007/BF00293954
language
English
LU publication?
yes
id
de1a9399-b5e0-487e-9bbe-5293dc245d58 (old id 1105923)
date added to LUP
2008-08-04 14:07:55
date last changed
2017-01-01 07:23:40
@article{de1a9399-b5e0-487e-9bbe-5293dc245d58,
  abstract     = {Extravasated endogenous serum albumin and fibrinogen were identified immunohistochemically in coronal brain sections from normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) after permanent ligation of the right middle cerebral artery. Infarcts were seen in all the SHR but only in 6 out of 14 WKY. Six hours after ligation, extravasated proteins were located primarily within the borders of the infarcts whereas after 24 h and later there was an increasing spread in the white matter. After 7 days, a protein immunoreactivity was seen far outside the infarcted areas, mainly in the white matter and occasionally extending somewhat into the contralateral side. Three weeks after permanent ligation, the immunoreactivity for plasma proteins had a similar extension but was less intense than after 7 days. A gliosis was noted within the protein-positive regions. From 72 h and onwards the immunoreactivity for albumin but not for fibrinogen extended via the white matter into the ipsilateral thalamic nuclei, where marked, mainly cytolytic nerve cell damage and gliosis was found. The close spatial correlation with albumin immunopositivity and the histological features of the thalamic lesions indicate that the propagation of extravasated plasma constituents or degradation products from the infarct may influence the character, timing and extent of remote tissue changes after cerebral infarction.},
  author       = {Nordborg, Claes and Sokrab, T E and Johansson, Barbro},
  issn         = {1432-0533},
  keyword      = {Brain infarct,vasogenic edema,thalamus,neuron,degeneration},
  language     = {eng},
  number       = {2},
  pages        = {118--126},
  publisher    = {Springer},
  series       = {Acta Neuropathologica},
  title        = {The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction},
  url          = {http://dx.doi.org/10.1007/BF00293954},
  volume       = {82},
  year         = {1991},
}