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Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction--a comparative study in rat and man

Malmqvist, Ulf LU ; Arner, Anders LU and Uvelius, Bengt LU (1991) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 25(4). p.261-267
Abstract
Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bladder. In the human control detrusor the actin/myosin ratio was similar to that in the control rat. The isoform distribution of the myosin heavy chains differed between man and rat. In the biopsies from the patients with outlet obstruction and in the obstructed rat bladders the actin/myosin ratio was increased. A change in the myosin heavy chain... (More)
Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bladder. In the human control detrusor the actin/myosin ratio was similar to that in the control rat. The isoform distribution of the myosin heavy chains differed between man and rat. In the biopsies from the patients with outlet obstruction and in the obstructed rat bladders the actin/myosin ratio was increased. A change in the myosin heavy chain distribution in the obstructed bladders was observed for both species. The filamin/actin ratio increased significantly in the obstructed rat bladders and tended to increase in the obstructed human bladders. Desmin was the dominating intermediate filament protein. The desmin/actin ratio increased in obstructed bladders in man and in rat. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myosin, actin, desmin, filamin, urinary bladder, detrusor, smooth muscle, human
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
25
issue
4
pages
261 - 267
publisher
Taylor & Francis
external identifiers
  • pmid:1723535
  • scopus:0026356383
ISSN
0036-5599
DOI
10.3109/00365599109024556
language
English
LU publication?
yes
id
bcc7413c-a111-45ee-844e-22c03665f207 (old id 1106042)
date added to LUP
2008-08-01 11:17:59
date last changed
2017-02-22 11:44:23
@article{bcc7413c-a111-45ee-844e-22c03665f207,
  abstract     = {Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bladder. In the human control detrusor the actin/myosin ratio was similar to that in the control rat. The isoform distribution of the myosin heavy chains differed between man and rat. In the biopsies from the patients with outlet obstruction and in the obstructed rat bladders the actin/myosin ratio was increased. A change in the myosin heavy chain distribution in the obstructed bladders was observed for both species. The filamin/actin ratio increased significantly in the obstructed rat bladders and tended to increase in the obstructed human bladders. Desmin was the dominating intermediate filament protein. The desmin/actin ratio increased in obstructed bladders in man and in rat.},
  author       = {Malmqvist, Ulf and Arner, Anders and Uvelius, Bengt},
  issn         = {0036-5599},
  keyword      = {myosin,actin,desmin,filamin,urinary bladder,detrusor,smooth muscle,human},
  language     = {eng},
  number       = {4},
  pages        = {261--267},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction--a comparative study in rat and man},
  url          = {http://dx.doi.org/10.3109/00365599109024556},
  volume       = {25},
  year         = {1991},
}