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In vitro effects of a thromboxane A2-analogue U-46619 and noradrenaline on contractions of the human thoracic duct

Sjöberg, Trygve LU and Steen, Stig LU (1991) In Lymphology 24(3). p.113-115
Abstract
A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and... (More)
A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and pEC50-values of U-46619 were 142% and 9.5, respectively. Postjunctional alpha-adrenoceptors and thromboxane A2-receptors may play a role in the contractility of the human thoracic duct. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lymphology
volume
24
issue
3
pages
113 - 115
publisher
International Society of Lymphology
external identifiers
  • pmid:1753802
  • scopus:0026072252
ISSN
0024-7766
language
English
LU publication?
yes
id
84689388-80c9-4e35-8321-6e6a9c6a95ef (old id 1106078)
date added to LUP
2008-08-01 09:30:03
date last changed
2017-07-30 04:31:13
@article{84689388-80c9-4e35-8321-6e6a9c6a95ef,
  abstract     = {A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and pEC50-values of U-46619 were 142% and 9.5, respectively. Postjunctional alpha-adrenoceptors and thromboxane A2-receptors may play a role in the contractility of the human thoracic duct.},
  author       = {Sjöberg, Trygve and Steen, Stig},
  issn         = {0024-7766},
  language     = {eng},
  number       = {3},
  pages        = {113--115},
  publisher    = {International Society of Lymphology},
  series       = {Lymphology},
  title        = {In vitro effects of a thromboxane A2-analogue U-46619 and noradrenaline on contractions of the human thoracic duct},
  volume       = {24},
  year         = {1991},
}