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Total extracorporeal lung assist--a new clinical approach

Wetterberg, T and Steen, Stig LU (1991) In Intensive Care Medicine 17(2). p.73-77
Abstract
Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with surface-heparinized veno-right ventricular ECLA for 35 days. Cardiac output was stabilized by means of sedation, hypothermia (35 degrees C) and beta blockers (pulse rate less than 90) in order to match the maximal venous drainage achieved (5.5 l/min). A bypass flow around 85% of cardiac output resulted in mean arterial PO2 values between 9-13.6 kPa without any contribution from the lungs. Low platelet counts and a marked... (More)
Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with surface-heparinized veno-right ventricular ECLA for 35 days. Cardiac output was stabilized by means of sedation, hypothermia (35 degrees C) and beta blockers (pulse rate less than 90) in order to match the maximal venous drainage achieved (5.5 l/min). A bypass flow around 85% of cardiac output resulted in mean arterial PO2 values between 9-13.6 kPa without any contribution from the lungs. Low platelet counts and a marked bleeding tendency complicated treatment, even though no heparin was used during the last 24 days of ECLA. Weaning from the ventilator was accomplished 2 months after ECLA. Lung function tests show constant improvement. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Total extracorporeal lung assist, Surface heparinization, Veno-right ventricular bypass, Platelets
in
Intensive Care Medicine
volume
17
issue
2
pages
73 - 77
publisher
Springer
external identifiers
  • pmid:1865040
  • scopus:0025973041
ISSN
0342-4642
DOI
10.1007/BF01691426
language
English
LU publication?
yes
id
351aae27-9a1d-461e-9048-6b3d5a94215d (old id 1106087)
date added to LUP
2008-08-01 09:37:52
date last changed
2017-08-06 03:41:36
@article{351aae27-9a1d-461e-9048-6b3d5a94215d,
  abstract     = {Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with surface-heparinized veno-right ventricular ECLA for 35 days. Cardiac output was stabilized by means of sedation, hypothermia (35 degrees C) and beta blockers (pulse rate less than 90) in order to match the maximal venous drainage achieved (5.5 l/min). A bypass flow around 85% of cardiac output resulted in mean arterial PO2 values between 9-13.6 kPa without any contribution from the lungs. Low platelet counts and a marked bleeding tendency complicated treatment, even though no heparin was used during the last 24 days of ECLA. Weaning from the ventilator was accomplished 2 months after ECLA. Lung function tests show constant improvement.},
  author       = {Wetterberg, T and Steen, Stig},
  issn         = {0342-4642},
  keyword      = {Total extracorporeal lung assist,Surface heparinization,Veno-right ventricular bypass,Platelets},
  language     = {eng},
  number       = {2},
  pages        = {73--77},
  publisher    = {Springer},
  series       = {Intensive Care Medicine},
  title        = {Total extracorporeal lung assist--a new clinical approach},
  url          = {http://dx.doi.org/10.1007/BF01691426},
  volume       = {17},
  year         = {1991},
}