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Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment

Skov, L; Hellström-Westas, Lena LU ; Jacobsen, T; Greisen, G and Svenningsen, N W (1992) In Neuropediatrics 23(3). p.126-130
Abstract
Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following... (More)
Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following surfactant was not matched by a drop in total cerebral haemoglobin concentration. This suggests that cerebral blood volume and hence cerebral blood flow was maintained. In the following minutes there was an improvement in cerebral oxygenation as indicated by the rise in cerebral oxyhaemoglobin concentration in nearly all the infants. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuropediatrics
volume
23
issue
3
pages
126 - 130
publisher
Georg Thieme Verlag
external identifiers
  • pmid:1641080
  • scopus:0026719798
ISSN
0174-304X
language
English
LU publication?
yes
id
a4c58625-3c2c-4ec5-93cb-b1f2ef4c9062 (old id 1106161)
date added to LUP
2008-08-11 14:42:11
date last changed
2017-09-17 07:08:44
@article{a4c58625-3c2c-4ec5-93cb-b1f2ef4c9062,
  abstract     = {Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following surfactant was not matched by a drop in total cerebral haemoglobin concentration. This suggests that cerebral blood volume and hence cerebral blood flow was maintained. In the following minutes there was an improvement in cerebral oxygenation as indicated by the rise in cerebral oxyhaemoglobin concentration in nearly all the infants.},
  author       = {Skov, L and Hellström-Westas, Lena and Jacobsen, T and Greisen, G and Svenningsen, N W},
  issn         = {0174-304X},
  language     = {eng},
  number       = {3},
  pages        = {126--130},
  publisher    = {Georg Thieme Verlag},
  series       = {Neuropediatrics},
  title        = {Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment},
  volume       = {23},
  year         = {1992},
}