Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment
(1992) In Neuropediatrics 23(3). p.126-130- Abstract
- Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following... (More)
- Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following surfactant was not matched by a drop in total cerebral haemoglobin concentration. This suggests that cerebral blood volume and hence cerebral blood flow was maintained. In the following minutes there was an improvement in cerebral oxygenation as indicated by the rise in cerebral oxyhaemoglobin concentration in nearly all the infants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106161
- author
- Skov, L ; Hellström-Westas, Lena LU ; Jacobsen, T ; Greisen, G and Svenningsen, N W
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuropediatrics
- volume
- 23
- issue
- 3
- pages
- 126 - 130
- publisher
- Georg Thieme Verlag
- external identifiers
-
- pmid:1641080
- scopus:0026719798
- ISSN
- 0174-304X
- language
- English
- LU publication?
- yes
- id
- a4c58625-3c2c-4ec5-93cb-b1f2ef4c9062 (old id 1106161)
- date added to LUP
- 2016-04-01 16:06:22
- date last changed
- 2021-09-19 03:07:34
@article{a4c58625-3c2c-4ec5-93cb-b1f2ef4c9062,
abstract = {{Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following surfactant was not matched by a drop in total cerebral haemoglobin concentration. This suggests that cerebral blood volume and hence cerebral blood flow was maintained. In the following minutes there was an improvement in cerebral oxygenation as indicated by the rise in cerebral oxyhaemoglobin concentration in nearly all the infants.}},
author = {{Skov, L and Hellström-Westas, Lena and Jacobsen, T and Greisen, G and Svenningsen, N W}},
issn = {{0174-304X}},
language = {{eng}},
number = {{3}},
pages = {{126--130}},
publisher = {{Georg Thieme Verlag}},
series = {{Neuropediatrics}},
title = {{Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment}},
volume = {{23}},
year = {{1992}},
}