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Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

Nannmark, U; Sennerby, L; Bjursten, Lars Magnus LU ; Skolnik, G and Bagge, U (1992) In Cancer Letters 62(1). p.83-86
Abstract
Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lodgement, phagocytes, tumour cells, liver, serotonin (5-HT)
in
Cancer Letters
volume
62
issue
1
pages
83 - 86
publisher
Elsevier
external identifiers
  • pmid:1540935
  • scopus:0026570929
ISSN
1872-7980
DOI
10.1016/0304-3835(92)90202-7
language
English
LU publication?
no
id
e3a26af3-e67a-4315-b05c-f145dad4eaaf (old id 1106223)
date added to LUP
2008-08-08 14:23:47
date last changed
2017-01-01 06:50:28
@article{e3a26af3-e67a-4315-b05c-f145dad4eaaf,
  abstract     = {Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.},
  author       = {Nannmark, U and Sennerby, L and Bjursten, Lars Magnus and Skolnik, G and Bagge, U},
  issn         = {1872-7980},
  keyword      = {lodgement,phagocytes,tumour cells,liver,serotonin (5-HT)},
  language     = {eng},
  number       = {1},
  pages        = {83--86},
  publisher    = {Elsevier},
  series       = {Cancer Letters},
  title        = {Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction},
  url          = {http://dx.doi.org/10.1016/0304-3835(92)90202-7},
  volume       = {62},
  year         = {1992},
}