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Soft tissue leiomyosarcoma. A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA content

Gustafson, Pelle LU ; Willen, Helena ; Baldetorp, Bo LU ; Fernö, Mårten LU ; Åkerman, Måns LU and Rydholm, Anders LU (1992) In Cancer 70(1). p.114-119
Abstract
BACKGROUND. Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS. Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not included. RESULTS. The annual incidence was 0.13/10(5). The ratio of men to women was 1.2, and the median age was 65 years. The thigh was the most common location. Almost half of the tumors were subcutaneous. The median tumor size was 6 cm (range, 1-25 cm). All patients were treated with surgery, and in 19 cases it was combined with adjuvant radiation... (More)
BACKGROUND. Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS. Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not included. RESULTS. The annual incidence was 0.13/10(5). The ratio of men to women was 1.2, and the median age was 65 years. The thigh was the most common location. Almost half of the tumors were subcutaneous. The median tumor size was 6 cm (range, 1-25 cm). All patients were treated with surgery, and in 19 cases it was combined with adjuvant radiation therapy or chemotherapy. The cumulative 5-year survival rate was 64%. Multivariate analysis indicated that age of 60 years or greater (relative risk [RR] = 8) and intratumoral vascular invasion (RR = 4) were independent risk factors for death resulting from tumor. DNA aneuploidy (RR = 4) and tumor necrosis (RR = 3) were associated with poor prognosis, but did not reach statistic significance. CONCLUSIONS. Advanced age, vascular invasion, and DNA aneuploidy could be used to identify prognostic subgroups. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
soft tissue sarcoma, leiomyosarcoma, epidemiology, prognosis, population-based, multivariate analysis, DNA content
in
Cancer
volume
70
issue
1
pages
114 - 119
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:1606532
  • scopus:0026689887
ISSN
1097-0142
DOI
10.1002/1097-0142(19920701)70:1<114::AID-CNCR2820700119>3.0.CO;2-U
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Department of Orthopaedics (Lund) (013028000)
id
237b9c2c-0113-4124-b84e-95e19cf0a904 (old id 1106287)
date added to LUP
2016-04-01 12:11:46
date last changed
2021-09-26 05:01:45
@article{237b9c2c-0113-4124-b84e-95e19cf0a904,
  abstract     = {{BACKGROUND. Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS. Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not included. RESULTS. The annual incidence was 0.13/10(5). The ratio of men to women was 1.2, and the median age was 65 years. The thigh was the most common location. Almost half of the tumors were subcutaneous. The median tumor size was 6 cm (range, 1-25 cm). All patients were treated with surgery, and in 19 cases it was combined with adjuvant radiation therapy or chemotherapy. The cumulative 5-year survival rate was 64%. Multivariate analysis indicated that age of 60 years or greater (relative risk [RR] = 8) and intratumoral vascular invasion (RR = 4) were independent risk factors for death resulting from tumor. DNA aneuploidy (RR = 4) and tumor necrosis (RR = 3) were associated with poor prognosis, but did not reach statistic significance. CONCLUSIONS. Advanced age, vascular invasion, and DNA aneuploidy could be used to identify prognostic subgroups.}},
  author       = {{Gustafson, Pelle and Willen, Helena and Baldetorp, Bo and Fernö, Mårten and Åkerman, Måns and Rydholm, Anders}},
  issn         = {{1097-0142}},
  keywords     = {{soft tissue sarcoma; leiomyosarcoma; epidemiology; prognosis; population-based; multivariate analysis; DNA content}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{114--119}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Cancer}},
  title        = {{Soft tissue leiomyosarcoma. A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA content}},
  url          = {{http://dx.doi.org/10.1002/1097-0142(19920701)70:1<114::AID-CNCR2820700119>3.0.CO;2-U}},
  doi          = {{10.1002/1097-0142(19920701)70:1<114::AID-CNCR2820700119>3.0.CO;2-U}},
  volume       = {{70}},
  year         = {{1992}},
}