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Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome

Fernö, Mårten LU ; Baldetorp, Bo LU ; Borg, Åke LU ; Olsson, Håkan LU ; Sigurdsson, Helgi and Killander, Dick LU (1992) In Acta Oncologica 31(2). p.157-165
Abstract
One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small... (More)
One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small increase in DNA content (near-hyperdiploid), those with a small decrease of DNA content (hypodiploid) manifested a more aggressive disease. In multivariate analysis, S-phase fraction (SPF) was a more important prognostic factor than both the improved or the conventional ploidy classification. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, flow cytometry, DNA-index, ploidy, S-phase, interphase, proliferation, prognosis
in
Acta Oncologica
volume
31
issue
2
pages
157 - 165
publisher
Taylor & Francis
external identifiers
  • pmid:1622630
  • scopus:0026724683
ISSN
1651-226X
DOI
10.3109/02841869209088897
language
English
LU publication?
yes
id
23f9cac5-4228-4060-9ef0-4e18f24c700d (old id 1106302)
date added to LUP
2008-08-01 14:23:39
date last changed
2017-02-19 04:12:15
@article{23f9cac5-4228-4060-9ef0-4e18f24c700d,
  abstract     = {One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small increase in DNA content (near-hyperdiploid), those with a small decrease of DNA content (hypodiploid) manifested a more aggressive disease. In multivariate analysis, S-phase fraction (SPF) was a more important prognostic factor than both the improved or the conventional ploidy classification.},
  author       = {Fernö, Mårten and Baldetorp, Bo and Borg, Åke and Olsson, Håkan and Sigurdsson, Helgi and Killander, Dick},
  issn         = {1651-226X},
  keyword      = {Breast cancer,flow cytometry,DNA-index,ploidy,S-phase,interphase,proliferation,prognosis},
  language     = {eng},
  number       = {2},
  pages        = {157--165},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome},
  url          = {http://dx.doi.org/10.3109/02841869209088897},
  volume       = {31},
  year         = {1992},
}