Normal tissue reactions in mice after combined treatment with metoclopramide and ionizing radiation
Lybak, Stein ; Kjellén, Elisabeth LU ; Nilsson, Per LU
; Tomaszewicz, Andrejs
; Wennerberg, Johan
LU
and Pero, Ronald
LU
(1992)
In Acta Oncologica
31(4).
p.469-474
- Abstract
- We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival... (More)
- We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival after whole body irradiation was studied in heterozygote Balb/c nu/+ mice as a measure of bone marrow toxicity. Metoclopramide was not found to affect the LD50/30 in this in vivo model. The absence of potentiation of radiation damage to normal tissue in these animal studies, makes metoclopramide an interesting possibility for future clinical evaluation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106375
- author
- Lybak, Stein
; Kjellén, Elisabeth
LU
; Nilsson, Per
LU
; Tomaszewicz, Andrejs
; Wennerberg, Johan
LU
and Pero, Ronald
LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 31
- issue
- 4
- pages
- 469 - 474
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:1632984
- scopus:0026653392
- ISSN
- 1651-226X
- DOI
- 10.3109/02841869209088291
- language
- English
- LU publication?
- yes
- id
- c719a65d-9127-4c4b-b479-51d7b6457a32 (old id 1106375)
- date added to LUP
- 2016-04-01 15:50:01
- date last changed
- 2021-01-03 04:20:02
@article{c719a65d-9127-4c4b-b479-51d7b6457a32,
abstract = {{We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival after whole body irradiation was studied in heterozygote Balb/c nu/+ mice as a measure of bone marrow toxicity. Metoclopramide was not found to affect the LD50/30 in this in vivo model. The absence of potentiation of radiation damage to normal tissue in these animal studies, makes metoclopramide an interesting possibility for future clinical evaluation.}},
author = {{Lybak, Stein and Kjellén, Elisabeth and Nilsson, Per and Tomaszewicz, Andrejs and Wennerberg, Johan and Pero, Ronald}},
issn = {{1651-226X}},
language = {{eng}},
number = {{4}},
pages = {{469--474}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{Normal tissue reactions in mice after combined treatment with metoclopramide and ionizing radiation}},
url = {{http://dx.doi.org/10.3109/02841869209088291}},
doi = {{10.3109/02841869209088291}},
volume = {{31}},
year = {{1992}},
}