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Normal tissue reactions in mice after combined treatment with metoclopramide and ionizing radiation

Lybak, Stein; Kjellén, Elisabeth LU ; Nilsson, Per LU ; Tomaszewicz, Andrejs; Wennerberg, Johan LU and Pero, Ronald LU (1992) In Acta Oncologica 31(4). p.469-474
Abstract
We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival... (More)
We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival after whole body irradiation was studied in heterozygote Balb/c nu/+ mice as a measure of bone marrow toxicity. Metoclopramide was not found to affect the LD50/30 in this in vivo model. The absence of potentiation of radiation damage to normal tissue in these animal studies, makes metoclopramide an interesting possibility for future clinical evaluation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
31
issue
4
pages
469 - 474
publisher
Taylor & Francis
external identifiers
  • pmid:1632984
  • scopus:0026653392
ISSN
1651-226X
DOI
10.3109/02841869209088291
language
English
LU publication?
yes
id
c719a65d-9127-4c4b-b479-51d7b6457a32 (old id 1106375)
date added to LUP
2008-08-08 12:46:56
date last changed
2017-01-01 06:48:01
@article{c719a65d-9127-4c4b-b479-51d7b6457a32,
  abstract     = {We have previously shown that metoclopramide potentiates the effect of ionizing radiation and cisplatin treatment of human squamous cell carcinomas from the head and neck region xenografted to nude mice. In the present tumor study, the dose scheduling of metoclopramide in combination with radiation was evaluated, and metoclopramide was shown to be most effective in potentiating the cytotoxic effect of radiation when administered one hour before radiation. The effect of radiation in combination with metoclopramide on normal tissue was also studied in two well-established models. Acute skin reactions to radiation exposure were studied in 129-type mice, and metoclopramide did not enhance the acute skin reaction in this in vivo model. Survival after whole body irradiation was studied in heterozygote Balb/c nu/+ mice as a measure of bone marrow toxicity. Metoclopramide was not found to affect the LD50/30 in this in vivo model. The absence of potentiation of radiation damage to normal tissue in these animal studies, makes metoclopramide an interesting possibility for future clinical evaluation.},
  author       = {Lybak, Stein and Kjellén, Elisabeth and Nilsson, Per and Tomaszewicz, Andrejs and Wennerberg, Johan and Pero, Ronald},
  issn         = {1651-226X},
  language     = {eng},
  number       = {4},
  pages        = {469--474},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Normal tissue reactions in mice after combined treatment with metoclopramide and ionizing radiation},
  url          = {http://dx.doi.org/10.3109/02841869209088291},
  volume       = {31},
  year         = {1992},
}