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Neuropsychological performance differs between type 1 diabetic and normal men during insulin-induced hypoglycaemia

Wirsen, A; Tallroth, G; Lindgren, Magnus LU and Agardh, Carl-David LU (1992) In Diabetic Medicine 9(2). p.156-165
Abstract
Cerebral function was measured with a neuropsychological test battery before, during, and after insulin-induced hypoglycaemia (blood glucose approximately 2.0 mmol l-1) in 10 male Type 1 diabetic patients (age 20-43 years, duration of diabetes 14 (2-30) years) and in 12 normal men. There were no group differences in neuropsychological results at normal glucose levels. Significant effects of hypoglycaemia were found in reaction-time measures (p less than 0.001) and in other tests requiring speed and attention (p less than 0.001), in verbal fluency (p less than 0.05), and short-term memory (p less than 0.001). Significant group effects and interactions (p less than 0.05) revealed that the diabetic patients were generally more affected by... (More)
Cerebral function was measured with a neuropsychological test battery before, during, and after insulin-induced hypoglycaemia (blood glucose approximately 2.0 mmol l-1) in 10 male Type 1 diabetic patients (age 20-43 years, duration of diabetes 14 (2-30) years) and in 12 normal men. There were no group differences in neuropsychological results at normal glucose levels. Significant effects of hypoglycaemia were found in reaction-time measures (p less than 0.001) and in other tests requiring speed and attention (p less than 0.001), in verbal fluency (p less than 0.05), and short-term memory (p less than 0.001). Significant group effects and interactions (p less than 0.05) revealed that the diabetic patients were generally more affected by hypoglycaemia than the normal subjects. This might have been partly due to the larger absolute decrease in blood glucose level in the diabetic patients, although the rate of glucose decrease was not related to performance in either group. Thus, the diabetic brain might be more vulnerable to hypoglycaemia, perhaps through the persistent impact of repeated hypoglycaemic episodes, although no neuropsychological deficit is demonstrable at normal blood glucose levels. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine
volume
9
issue
2
pages
156 - 165
publisher
Wiley-Blackwell
external identifiers
  • pmid:1563251
  • scopus:0026562211
ISSN
1464-5491
language
English
LU publication?
yes
id
46bc42d7-c63b-4581-bb01-730f5fd43287 (old id 1106585)
date added to LUP
2008-08-12 08:45:35
date last changed
2017-05-07 04:15:53
@article{46bc42d7-c63b-4581-bb01-730f5fd43287,
  abstract     = {Cerebral function was measured with a neuropsychological test battery before, during, and after insulin-induced hypoglycaemia (blood glucose approximately 2.0 mmol l-1) in 10 male Type 1 diabetic patients (age 20-43 years, duration of diabetes 14 (2-30) years) and in 12 normal men. There were no group differences in neuropsychological results at normal glucose levels. Significant effects of hypoglycaemia were found in reaction-time measures (p less than 0.001) and in other tests requiring speed and attention (p less than 0.001), in verbal fluency (p less than 0.05), and short-term memory (p less than 0.001). Significant group effects and interactions (p less than 0.05) revealed that the diabetic patients were generally more affected by hypoglycaemia than the normal subjects. This might have been partly due to the larger absolute decrease in blood glucose level in the diabetic patients, although the rate of glucose decrease was not related to performance in either group. Thus, the diabetic brain might be more vulnerable to hypoglycaemia, perhaps through the persistent impact of repeated hypoglycaemic episodes, although no neuropsychological deficit is demonstrable at normal blood glucose levels.},
  author       = {Wirsen, A and Tallroth, G and Lindgren, Magnus and Agardh, Carl-David},
  issn         = {1464-5491},
  language     = {eng},
  number       = {2},
  pages        = {156--165},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Neuropsychological performance differs between type 1 diabetic and normal men during insulin-induced hypoglycaemia},
  volume       = {9},
  year         = {1992},
}