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Quantitative single photon emission tomography: verification for sources in an elliptical water phantom

Ljungberg, Michael LU orcid ; King, Michael A and Strand, Sven-Erik LU (1992) In European Journal Of Nuclear Medicine 19(10). p.838-844
Abstract
Accurate absorbed dose calculations are important for a proper dose planning in internal radionuclide therapy. The activity distribution must be measured and the target volume defined. This can be done with single photon emission tomography (SPET) if proper attenuation and scatter correction are employed. This study investigated the calculation of the activity and the volume of different spherical sources. These two parameters are essential for a proper dose calculation. The scatter and attenuation correction method is based on spatially variant scatter functions and density maps. The volume calculation method is based on obtaining a threshold from a grey-level histogram. Both point sources and spheres of different diameters containing... (More)
Accurate absorbed dose calculations are important for a proper dose planning in internal radionuclide therapy. The activity distribution must be measured and the target volume defined. This can be done with single photon emission tomography (SPET) if proper attenuation and scatter correction are employed. This study investigated the calculation of the activity and the volume of different spherical sources. These two parameters are essential for a proper dose calculation. The scatter and attenuation correction method is based on spatially variant scatter functions and density maps. The volume calculation method is based on obtaining a threshold from a grey-level histogram. Both point sources and spheres of different diameters containing technetium-99m were placed in different locations in an elliptical water phantom and imaged by SPET. The activity and the volume of the spheres were calculated from the SPET images and compared with known activities. Results show a quantification of activity within 10% for most of the sources. Important influences on the quantification are (a) the presence of artefacts due to improper reconstruction and (b) the finite spatial resolution which affects the total number of counts within the determined volume. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Monte Carlo, Single photon emission tomography, Scatter, Attenuation, Absorbed dose, Volume, Quantification
in
European Journal Of Nuclear Medicine
volume
19
issue
10
pages
838 - 844
publisher
Springer
external identifiers
  • pmid:1451697
  • scopus:0026739596
ISSN
1432-105X
DOI
10.1007/BF00168157
language
English
LU publication?
yes
id
8fffd691-7a3c-4b95-b7ef-4bf940f59d0b (old id 1106602)
date added to LUP
2016-04-01 12:14:58
date last changed
2024-01-08 13:38:49
@article{8fffd691-7a3c-4b95-b7ef-4bf940f59d0b,
  abstract     = {{Accurate absorbed dose calculations are important for a proper dose planning in internal radionuclide therapy. The activity distribution must be measured and the target volume defined. This can be done with single photon emission tomography (SPET) if proper attenuation and scatter correction are employed. This study investigated the calculation of the activity and the volume of different spherical sources. These two parameters are essential for a proper dose calculation. The scatter and attenuation correction method is based on spatially variant scatter functions and density maps. The volume calculation method is based on obtaining a threshold from a grey-level histogram. Both point sources and spheres of different diameters containing technetium-99m were placed in different locations in an elliptical water phantom and imaged by SPET. The activity and the volume of the spheres were calculated from the SPET images and compared with known activities. Results show a quantification of activity within 10% for most of the sources. Important influences on the quantification are (a) the presence of artefacts due to improper reconstruction and (b) the finite spatial resolution which affects the total number of counts within the determined volume.}},
  author       = {{Ljungberg, Michael and King, Michael A and Strand, Sven-Erik}},
  issn         = {{1432-105X}},
  keywords     = {{Monte Carlo; Single photon emission tomography; Scatter; Attenuation; Absorbed dose; Volume; Quantification}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{838--844}},
  publisher    = {{Springer}},
  series       = {{European Journal Of Nuclear Medicine}},
  title        = {{Quantitative single photon emission tomography: verification for sources in an elliptical water phantom}},
  url          = {{http://dx.doi.org/10.1007/BF00168157}},
  doi          = {{10.1007/BF00168157}},
  volume       = {{19}},
  year         = {{1992}},
}