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Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats

Grabowski, Martin LU ; Christofferson, R H; Brundin, Patrik LU and Johansson, Barbro LU (1992) In Neuroscience 51(3). p.673-682
Abstract
The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained... (More)
The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained leptomeningeal vessels intermingled with a thin capillary network which is not normally found on the brain surface. The graft vessels were derived from this vascular plexus. The regular pattern of arterioles and venules penetrating from the cortical surface in normal neocortex was absent in the grafts but the capillary morphology was similar in both types of tissue. The grafts had a lower capillary density than normal tissue and lacked the laminar distribution of capillaries characteristic of normal neocortex. The results demonstrate the plasticity of the vascular system where remodeling of the vascular tree after an ischemic insult provides suitable conditions for the vascularization of neocortical grafts. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience
volume
51
issue
3
pages
673 - 682
publisher
Elsevier
external identifiers
  • pmid:1488117
  • scopus:0026447581
ISSN
1873-7544
DOI
10.1016/0306-4522(92)90306-M
language
English
LU publication?
yes
id
ad6c6fa9-d0f1-4493-ace9-311b95702d2c (old id 1106605)
date added to LUP
2008-08-01 15:33:25
date last changed
2017-08-27 03:50:36
@article{ad6c6fa9-d0f1-4493-ace9-311b95702d2c,
  abstract     = {The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained leptomeningeal vessels intermingled with a thin capillary network which is not normally found on the brain surface. The graft vessels were derived from this vascular plexus. The regular pattern of arterioles and venules penetrating from the cortical surface in normal neocortex was absent in the grafts but the capillary morphology was similar in both types of tissue. The grafts had a lower capillary density than normal tissue and lacked the laminar distribution of capillaries characteristic of normal neocortex. The results demonstrate the plasticity of the vascular system where remodeling of the vascular tree after an ischemic insult provides suitable conditions for the vascularization of neocortical grafts.},
  author       = {Grabowski, Martin and Christofferson, R H and Brundin, Patrik and Johansson, Barbro},
  issn         = {1873-7544},
  language     = {eng},
  number       = {3},
  pages        = {673--682},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats},
  url          = {http://dx.doi.org/10.1016/0306-4522(92)90306-M},
  volume       = {51},
  year         = {1992},
}