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Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide

Andersson, Sven LU (1992) In European Journal of Pharmacology 224(1). p.89-91
Abstract
Calcitonin gene-related peptide (CGRP) given i.v. to rabbits induced hypotension and a breakdown of the blood-aqueous barrier. Glibenclamide, a blocker of ATP-sensitive K+ (K+ATP) channels antagonized both these effects. The K+ATP channel opener diazoxide reduced blood pressure but did not damage the blood-aqueous barrier. Inhibition of nitric oxide synthase antagonized the effects of CGRP on the blood-aqueous barrier but did not attenuate the hypotensive response. The results suggest that vasodilatation induced by the opening of K+ATP channels is a prerequisite for the effect of CGRP on the blood-aqueous barrier.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
K+ channels (ATP-sensitive), Blood-aqueous barrier, Nitric oxide (NO), Vasodilatation
in
European Journal of Pharmacology
volume
224
issue
1
pages
89 - 91
publisher
Elsevier
external identifiers
  • pmid:1280598
  • scopus:0026615277
ISSN
1879-0712
DOI
10.1016/0014-2999(92)94823-E
language
English
LU publication?
yes
id
65d68ba5-d10f-4d3f-be37-ba76ff6e78f7 (old id 1106913)
date added to LUP
2016-04-01 11:41:12
date last changed
2020-01-12 08:24:16
@article{65d68ba5-d10f-4d3f-be37-ba76ff6e78f7,
  abstract     = {Calcitonin gene-related peptide (CGRP) given i.v. to rabbits induced hypotension and a breakdown of the blood-aqueous barrier. Glibenclamide, a blocker of ATP-sensitive K+ (K+ATP) channels antagonized both these effects. The K+ATP channel opener diazoxide reduced blood pressure but did not damage the blood-aqueous barrier. Inhibition of nitric oxide synthase antagonized the effects of CGRP on the blood-aqueous barrier but did not attenuate the hypotensive response. The results suggest that vasodilatation induced by the opening of K+ATP channels is a prerequisite for the effect of CGRP on the blood-aqueous barrier.},
  author       = {Andersson, Sven},
  issn         = {1879-0712},
  language     = {eng},
  number       = {1},
  pages        = {89--91},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide},
  url          = {http://dx.doi.org/10.1016/0014-2999(92)94823-E},
  doi          = {10.1016/0014-2999(92)94823-E},
  volume       = {224},
  year         = {1992},
}