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Liposarcoma: a population-based epidemiologic and prognostic study of features of 43 patients, including tumor DNA content

Gustafson, Pelle LU ; Rydholm, Anders LU ; Willén, Helena; Baldetorp, Bo LU ; Fernö, Mårten LU and Åkerman, Måns LU (1993) In International Journal of Cancer 55(4). p.541-546
Abstract
Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis... (More)
Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis increasing malignancy grade, tumor necrosis, vascular invasion, mitotic count, subtype other than well-differentiated, and high cellularity were prognostic for metastatic disease. However, in the multivariate analysis only tumor necrosis was an independent risk factor. Tumor necrosis should be considered when prognosis of liposarcoma of the extremity and trunk wall is evaluated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
55
issue
4
pages
541 - 546
publisher
John Wiley & Sons
external identifiers
  • pmid:8406979
  • scopus:0027438514
ISSN
0020-7136
DOI
10.1002/ijc.2910550404
language
English
LU publication?
yes
id
c5b1f2c3-0f1d-4501-9fee-91f6bf16356e (old id 1107012)
date added to LUP
2008-07-30 09:30:11
date last changed
2017-01-01 04:50:12
@article{c5b1f2c3-0f1d-4501-9fee-91f6bf16356e,
  abstract     = {Different conceptions exist regarding the epidemiology and prognosis of liposarcoma, and several classification systems are in use. We analyzed a population-based, 25-year series of 43 patients with liposarcoma of the extremity or trunk wall. Follow-up was complete. The annual incidence was 0.12/10(5). The thigh was the most common location. One of 6 tumors was subcutaneous. Deep-seated tumors were larger than s.c. tumors. Among the 42 surgically treated patients, grade II (4-grade scale) was the most common malignancy grade. Four tumors were well-differentiated, 24 were predominantly myxoid, 4 predominantly round-cell, and 10 were predominantly of pleomorphic type. The 5-year metastasis-free survival rate was 69%. By univariate analysis increasing malignancy grade, tumor necrosis, vascular invasion, mitotic count, subtype other than well-differentiated, and high cellularity were prognostic for metastatic disease. However, in the multivariate analysis only tumor necrosis was an independent risk factor. Tumor necrosis should be considered when prognosis of liposarcoma of the extremity and trunk wall is evaluated.},
  author       = {Gustafson, Pelle and Rydholm, Anders and Willén, Helena and Baldetorp, Bo and Fernö, Mårten and Åkerman, Måns},
  issn         = {0020-7136},
  language     = {eng},
  number       = {4},
  pages        = {541--546},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Liposarcoma: a population-based epidemiologic and prognostic study of features of 43 patients, including tumor DNA content},
  url          = {http://dx.doi.org/10.1002/ijc.2910550404},
  volume       = {55},
  year         = {1993},
}