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T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy

Tennvall, Jan LU ; Wennerberg, Johan LU ; Willen, R; Ask, Anders LU ; Baldetorp, Bo LU and Fernö, Mårten LU (1993) In Acta Oto-Laryngologica 113(1). p.220-224
Abstract
In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local... (More)
In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laryngeal carcinoma, recurrence, proliferation, flow cytometry, hisroparhological grading system
in
Acta Oto-Laryngologica
volume
113
issue
1
pages
220 - 224
publisher
Taylor & Francis
external identifiers
  • pmid:8475740
  • scopus:0027526506
ISSN
1651-2251
DOI
10.3109/00016489309135796
language
English
LU publication?
yes
id
f8009b21-b518-4241-ab77-e6d7bceb0543 (old id 1107049)
date added to LUP
2008-07-30 10:02:20
date last changed
2017-01-01 07:00:57
@article{f8009b21-b518-4241-ab77-e6d7bceb0543,
  abstract     = {In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p &lt; 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower.},
  author       = {Tennvall, Jan and Wennerberg, Johan and Willen, R and Ask, Anders and Baldetorp, Bo and Fernö, Mårten},
  issn         = {1651-2251},
  keyword      = {laryngeal carcinoma,recurrence,proliferation,flow cytometry,hisroparhological grading system},
  language     = {eng},
  number       = {1},
  pages        = {220--224},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy},
  url          = {http://dx.doi.org/10.3109/00016489309135796},
  volume       = {113},
  year         = {1993},
}