Advanced

Local host response in the lower respiratory tract in nephropathia epidemica

Linderholm, Mats; Bjermer, Leif LU ; Juto, Per; Roos, Göran; Sandstrom, Thomas; Settergren, Bo and Tarnvik, Arne (1993) In Scandinavian Journal of Infectious Diseases 25(5). p.639-646
Abstract
Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after... (More)
Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01), CD8+ T cells (p < 0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p < 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
25
issue
5
pages
639 - 646
publisher
Informa Healthcare
external identifiers
  • pmid:7904380
  • scopus:0027424836
ISSN
1651-1980
DOI
10.3109/00365549309008554
language
English
LU publication?
yes
id
d6afe053-cda9-44db-972d-206c16e20c58 (old id 1107087)
date added to LUP
2008-07-30 10:56:29
date last changed
2017-01-01 07:19:12
@article{d6afe053-cda9-44db-972d-206c16e20c58,
  abstract     = {Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p &lt; 0.05) and significantly higher numbers of lysozyme-positive macrophages (p &lt; 0.01), CD8+ T cells (p &lt; 0.01), and natural killer (NK) cells (p &lt; 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p &lt; 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection.},
  author       = {Linderholm, Mats and Bjermer, Leif and Juto, Per and Roos, Göran and Sandstrom, Thomas and Settergren, Bo and Tarnvik, Arne},
  issn         = {1651-1980},
  language     = {eng},
  number       = {5},
  pages        = {639--646},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Local host response in the lower respiratory tract in nephropathia epidemica},
  url          = {http://dx.doi.org/10.3109/00365549309008554},
  volume       = {25},
  year         = {1993},
}