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Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride

Jönsson, Bo A LU and Skerfving, Staffan LU (1993) In Scandinavian Journal of Work, Environment and Health 19(3). p.183-190
Abstract
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 micrograms.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hexahydrophthalic acid (HHP acid) were seen. During the first 4 h after the end of exposure, the half-time of HHP acid in plasma was about 2 h. A corresponding decay was seen in urine. The correlations (r > 0.90) between the air concentrations of HHPA and the levels of HHP acid in plasma and urine were close. They were even closer (r > 0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or... (More)
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 micrograms.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hexahydrophthalic acid (HHP acid) were seen. During the first 4 h after the end of exposure, the half-time of HHP acid in plasma was about 2 h. A corresponding decay was seen in urine. The correlations (r > 0.90) between the air concentrations of HHPA and the levels of HHP acid in plasma and urine were close. They were even closer (r > 0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or sodium hydrogen carbonate did not significantly alter the excretion of HHP acid. The results show that the analysis of HHP acid in plasma or urine is useful as a biological monitor for exposure to HHPA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Work, Environment and Health
volume
19
issue
3
pages
183 - 190
publisher
Finnish Institute of Occupational Health
external identifiers
  • pmid:8367696
  • scopus:0027236792
ISSN
0355-3140
language
English
LU publication?
yes
id
6feababc-7445-4ff6-8fa9-0589869b8ea1 (old id 1107094)
date added to LUP
2008-07-30 11:00:59
date last changed
2017-01-01 05:11:32
@article{6feababc-7445-4ff6-8fa9-0589869b8ea1,
  abstract     = {Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 micrograms.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma and urinary levels of hexahydrophthalic acid (HHP acid) were seen. During the first 4 h after the end of exposure, the half-time of HHP acid in plasma was about 2 h. A corresponding decay was seen in urine. The correlations (r > 0.90) between the air concentrations of HHPA and the levels of HHP acid in plasma and urine were close. They were even closer (r > 0.96) when the total respiratory uptake of HHPA was used. Urinary pH adjustment by intake of ammonium chloride or sodium hydrogen carbonate did not significantly alter the excretion of HHP acid. The results show that the analysis of HHP acid in plasma or urine is useful as a biological monitor for exposure to HHPA.},
  author       = {Jönsson, Bo A and Skerfving, Staffan},
  issn         = {0355-3140},
  language     = {eng},
  number       = {3},
  pages        = {183--190},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride},
  volume       = {19},
  year         = {1993},
}