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The effect of noradrenaline on mucociliary activity in the rabbit maxillary sinus

Cervin, Anders LU ; Lindberg, Sven LU and Mercke, Ulf LU (1993) In Rhinology 31(1). p.17-21
Abstract
The effect of noradrenaline (NA) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting it at increasing dosages (10(-11) to 10(-4) mol/kg) into the maxillary artery, the mucociliary response being recorded photoelectrically. NA increased mucociliary activity at a dosage of 10(-5) mol/kg, the maximal increase being 16.1 +/- 2.6%. The NA-induced stimulation of mucociliary activity had a latency of 20 s, and the activity returned to base-line level within 3 min. Pretreatment with the alpha-antagonist phentolamine (0.2 and 1.0 mg/kg) or the cholinergic antagonist atropine (1 mg/kg) did not alter mucociliary response to NA. Blockade with the beta-antagonist propranolol did not significantly reduce the... (More)
The effect of noradrenaline (NA) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting it at increasing dosages (10(-11) to 10(-4) mol/kg) into the maxillary artery, the mucociliary response being recorded photoelectrically. NA increased mucociliary activity at a dosage of 10(-5) mol/kg, the maximal increase being 16.1 +/- 2.6%. The NA-induced stimulation of mucociliary activity had a latency of 20 s, and the activity returned to base-line level within 3 min. Pretreatment with the alpha-antagonist phentolamine (0.2 and 1.0 mg/kg) or the cholinergic antagonist atropine (1 mg/kg) did not alter mucociliary response to NA. Blockade with the beta-antagonist propranolol did not significantly reduce the maximal response to NA, which was 16.1 +/- 2.6% before and 11.1 +/- 3.0% after pretreatment with propranolol (n = 7; p = 0.2). In contrast, pretreatment with the prostaglandin-synthesis inhibitor indomethacin reduced the response from 12.9 +/- 2.9% to 6.3 +/- 1.3% (n = 6; p < 0.05), suggesting that at high dosages NA stimulates mucociliary activity via the cyclo-oxygenase pathway. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rhinology
volume
31
issue
1
pages
17 - 21
publisher
International Rhinologic Society
external identifiers
  • pmid:8321977
  • scopus:0027232443
ISSN
0300-0729
language
English
LU publication?
yes
id
4e98233d-35d8-4fe3-a9d2-709b639294e5 (old id 1107128)
date added to LUP
2008-07-30 12:03:40
date last changed
2017-01-01 07:27:27
@article{4e98233d-35d8-4fe3-a9d2-709b639294e5,
  abstract     = {The effect of noradrenaline (NA) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting it at increasing dosages (10(-11) to 10(-4) mol/kg) into the maxillary artery, the mucociliary response being recorded photoelectrically. NA increased mucociliary activity at a dosage of 10(-5) mol/kg, the maximal increase being 16.1 +/- 2.6%. The NA-induced stimulation of mucociliary activity had a latency of 20 s, and the activity returned to base-line level within 3 min. Pretreatment with the alpha-antagonist phentolamine (0.2 and 1.0 mg/kg) or the cholinergic antagonist atropine (1 mg/kg) did not alter mucociliary response to NA. Blockade with the beta-antagonist propranolol did not significantly reduce the maximal response to NA, which was 16.1 +/- 2.6% before and 11.1 +/- 3.0% after pretreatment with propranolol (n = 7; p = 0.2). In contrast, pretreatment with the prostaglandin-synthesis inhibitor indomethacin reduced the response from 12.9 +/- 2.9% to 6.3 +/- 1.3% (n = 6; p &lt; 0.05), suggesting that at high dosages NA stimulates mucociliary activity via the cyclo-oxygenase pathway.},
  author       = {Cervin, Anders and Lindberg, Sven and Mercke, Ulf},
  issn         = {0300-0729},
  language     = {eng},
  number       = {1},
  pages        = {17--21},
  publisher    = {International Rhinologic Society},
  series       = {Rhinology},
  title        = {The effect of noradrenaline on mucociliary activity in the rabbit maxillary sinus},
  volume       = {31},
  year         = {1993},
}