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Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy

Mellstrom, D; Johansson, C; Johnell, Olof LU ; Lindstedt, G; Lundberg, P A; Obrant, Karl LU ; Schoon, I M; Toss, G and Ytterberg, B O (1993) In Calcified Tissue International 53(6). p.370-377
Abstract
A case-control study compared 129 men with earlier partial gastrectomy (operation during the period 1952-1961) with 216 men from a community-based population study. All were born 1910-1915 and the mean age was 72 years. Men with a previous partial gastrectomy had vertebral fractures in 19% compared with 4% (P < 0.01) in the control population. Bone mineral density (BMD) in the right calcaneus measured with dual energy photon absorptiometry was 20% lower in men with a Billroth II operation (P < 0.001) and 8% lower with a Billroth I operation (ns). In comparison with the controls, the men subjected to partial gastrectomy had higher serum concentrations of osteocalcin and alkaline phosphatase activity, a lower serum concentration of... (More)
A case-control study compared 129 men with earlier partial gastrectomy (operation during the period 1952-1961) with 216 men from a community-based population study. All were born 1910-1915 and the mean age was 72 years. Men with a previous partial gastrectomy had vertebral fractures in 19% compared with 4% (P < 0.01) in the control population. Bone mineral density (BMD) in the right calcaneus measured with dual energy photon absorptiometry was 20% lower in men with a Billroth II operation (P < 0.001) and 8% lower with a Billroth I operation (ns). In comparison with the controls, the men subjected to partial gastrectomy had higher serum concentrations of osteocalcin and alkaline phosphatase activity, a lower serum concentration of 25-hydroxyvitamin D (25OHD) and a lower body mass index (BMI). There were no difference in serum concentrations of free calcium, intact parathyroid hormone (PTH), or free thyroxine. The smoking prevalence was significantly higher in men with partial gastrectomy than in controls. Smokers had significantly lower serum concentrations of intact PTH and 25OHD than nonsmokers and also lower BMD and BMI. The relationships between intact PTH on one hand, and ionized calcium (inverse relationship) and osteocalcin (direct relationship) on the other were preserved in smokers, however. Gastroscopy was performed in 78 men with multiple biopsies in the gastric remnant and also in the small intestine. All but two subjects had chronic gastritis. Examination of sternal bone marrow smears showed that 40% of the Billroth-operated men lacked bone marrow reticular iron.(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Calcified Tissue International
volume
53
issue
6
pages
370 - 377
publisher
Springer
external identifiers
  • pmid:8293349
  • scopus:0027431052
ISSN
1432-0827
language
English
LU publication?
yes
id
ec1c413f-5492-4d8c-ba0c-c17cbe1204fd (old id 1107243)
date added to LUP
2008-07-30 14:31:13
date last changed
2017-05-07 04:19:57
@article{ec1c413f-5492-4d8c-ba0c-c17cbe1204fd,
  abstract     = {A case-control study compared 129 men with earlier partial gastrectomy (operation during the period 1952-1961) with 216 men from a community-based population study. All were born 1910-1915 and the mean age was 72 years. Men with a previous partial gastrectomy had vertebral fractures in 19% compared with 4% (P &lt; 0.01) in the control population. Bone mineral density (BMD) in the right calcaneus measured with dual energy photon absorptiometry was 20% lower in men with a Billroth II operation (P &lt; 0.001) and 8% lower with a Billroth I operation (ns). In comparison with the controls, the men subjected to partial gastrectomy had higher serum concentrations of osteocalcin and alkaline phosphatase activity, a lower serum concentration of 25-hydroxyvitamin D (25OHD) and a lower body mass index (BMI). There were no difference in serum concentrations of free calcium, intact parathyroid hormone (PTH), or free thyroxine. The smoking prevalence was significantly higher in men with partial gastrectomy than in controls. Smokers had significantly lower serum concentrations of intact PTH and 25OHD than nonsmokers and also lower BMD and BMI. The relationships between intact PTH on one hand, and ionized calcium (inverse relationship) and osteocalcin (direct relationship) on the other were preserved in smokers, however. Gastroscopy was performed in 78 men with multiple biopsies in the gastric remnant and also in the small intestine. All but two subjects had chronic gastritis. Examination of sternal bone marrow smears showed that 40% of the Billroth-operated men lacked bone marrow reticular iron.(ABSTRACT TRUNCATED AT 250 WORDS)},
  author       = {Mellstrom, D and Johansson, C and Johnell, Olof and Lindstedt, G and Lundberg, P A and Obrant, Karl and Schoon, I M and Toss, G and Ytterberg, B O},
  issn         = {1432-0827},
  language     = {eng},
  number       = {6},
  pages        = {370--377},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy},
  volume       = {53},
  year         = {1993},
}