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Radioimmunotherapy dosimetry--a review

Strand, Sven-Erik LU ; Jönsson, Bo-Anders LU ; Ljungberg, Michael LU and Tennvall, Jan LU (1993) In Acta Oncologica 32(7-8). p.807-817
Abstract
Results from therapeutic trials in systemic radiation therapy with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate dosimetry. This applies macroscopically as well as microscopically for both tumours and normal tissues. For treatment planning in radioimmunotherapy both the macroscopic and the microscopic absorbed dose distribution must be known. The former is based on a proper knowledge of parameters, such as activity quantitation techniques in both planar and SPECT imaging, different correction techniques, and high activity measurements. Absorbed dose calculations and treatment planning techniques are based on analytical or Monte Carlo calculations. The PET technique with higher resolution is also... (More)
Results from therapeutic trials in systemic radiation therapy with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate dosimetry. This applies macroscopically as well as microscopically for both tumours and normal tissues. For treatment planning in radioimmunotherapy both the macroscopic and the microscopic absorbed dose distribution must be known. The former is based on a proper knowledge of parameters, such as activity quantitation techniques in both planar and SPECT imaging, different correction techniques, and high activity measurements. Absorbed dose calculations and treatment planning techniques are based on analytical or Monte Carlo calculations. The PET technique with higher resolution is also suggested for radioimmunotherapy planning. Accurate in vivo absorbed dose measurement techniques to verify the calculated absorbed doses are needed in treatment planning. Monitoring the absorbed rate is desirable to assess radiobiological effect. Several ways of enhancing the therapeutic ratio are suggested, especially novel technique with extracorporeal immunoadsorption. An important topic is small scale dosimetry, which is based on techniques for detailed imaging of activity distributions to calculate the absorbed dose distribution. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
32
issue
7-8
pages
807 - 817
publisher
Taylor & Francis
external identifiers
  • pmid:8305230
  • scopus:0027762394
ISSN
1651-226X
DOI
10.3109/02841869309096140
language
English
LU publication?
yes
id
6326f92a-58bf-4db2-882a-668c44570830 (old id 1107365)
date added to LUP
2008-07-30 16:50:36
date last changed
2017-07-30 04:35:14
@article{6326f92a-58bf-4db2-882a-668c44570830,
  abstract     = {Results from therapeutic trials in systemic radiation therapy with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate dosimetry. This applies macroscopically as well as microscopically for both tumours and normal tissues. For treatment planning in radioimmunotherapy both the macroscopic and the microscopic absorbed dose distribution must be known. The former is based on a proper knowledge of parameters, such as activity quantitation techniques in both planar and SPECT imaging, different correction techniques, and high activity measurements. Absorbed dose calculations and treatment planning techniques are based on analytical or Monte Carlo calculations. The PET technique with higher resolution is also suggested for radioimmunotherapy planning. Accurate in vivo absorbed dose measurement techniques to verify the calculated absorbed doses are needed in treatment planning. Monitoring the absorbed rate is desirable to assess radiobiological effect. Several ways of enhancing the therapeutic ratio are suggested, especially novel technique with extracorporeal immunoadsorption. An important topic is small scale dosimetry, which is based on techniques for detailed imaging of activity distributions to calculate the absorbed dose distribution.},
  author       = {Strand, Sven-Erik and Jönsson, Bo-Anders and Ljungberg, Michael and Tennvall, Jan},
  issn         = {1651-226X},
  language     = {eng},
  number       = {7-8},
  pages        = {807--817},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Radioimmunotherapy dosimetry--a review},
  url          = {http://dx.doi.org/10.3109/02841869309096140},
  volume       = {32},
  year         = {1993},
}