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Mucosal exudation of plasma is a noninjurious intestinal defense mechanism

Persson, C G; Gustafsson, B; Erjefält, Jonas LU and Sundler, Frank LU (1993) In Allergy 48(8). p.581-586
Abstract
We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endointestinal allergen challenge, epithelial integrity, luminal entry of plasma, mucosal exudation
in
Allergy
volume
48
issue
8
pages
581 - 586
publisher
Wiley-Blackwell
external identifiers
  • pmid:8116857
  • scopus:0027436575
ISSN
1398-9995
DOI
10.1111/j.1398-9995.1993.tb00752.x
language
English
LU publication?
yes
id
926bab1e-4245-4054-97c8-f37eee147031 (old id 1107656)
date added to LUP
2008-07-31 14:14:08
date last changed
2017-08-20 04:29:26
@article{926bab1e-4245-4054-97c8-f37eee147031,
  abstract     = {We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.},
  author       = {Persson, C G and Gustafsson, B and Erjefält, Jonas and Sundler, Frank},
  issn         = {1398-9995},
  keyword      = {endointestinal allergen challenge,epithelial integrity,luminal entry of plasma,mucosal exudation},
  language     = {eng},
  number       = {8},
  pages        = {581--586},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Mucosal exudation of plasma is a noninjurious intestinal defense mechanism},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.1993.tb00752.x},
  volume       = {48},
  year         = {1993},
}