Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour
(1994) In Journal of Biomaterials Science. Polymer Edition 6(5). p.411-423- Abstract
- Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the... (More)
- Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107765
- author
- Löfgren, Anders ; Albertsson, Ann-Christine ; Zhang, Yanzhen and Bjursten, Lars Magnus LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Degradation, In vivo, copolymers, polyesters, aliphatic
- in
- Journal of Biomaterials Science. Polymer Edition
- volume
- 6
- issue
- 5
- pages
- 411 - 423
- publisher
- VSP BV
- external identifiers
-
- pmid:7841148
- scopus:84947384287
- ISSN
- 0920-5063
- DOI
- 10.1163/156856294X00400
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- b19973bf-aaee-4f9d-a8fd-791e9c7690f0 (old id 1107765)
- date added to LUP
- 2016-04-01 17:07:56
- date last changed
- 2021-01-03 05:19:02
@article{b19973bf-aaee-4f9d-a8fd-791e9c7690f0, abstract = {{Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one.}}, author = {{Löfgren, Anders and Albertsson, Ann-Christine and Zhang, Yanzhen and Bjursten, Lars Magnus}}, issn = {{0920-5063}}, keywords = {{Degradation; In vivo; copolymers; polyesters; aliphatic}}, language = {{eng}}, number = {{5}}, pages = {{411--423}}, publisher = {{VSP BV}}, series = {{Journal of Biomaterials Science. Polymer Edition}}, title = {{Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour}}, url = {{http://dx.doi.org/10.1163/156856294X00400}}, doi = {{10.1163/156856294X00400}}, volume = {{6}}, year = {{1994}}, }