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Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour

Löfgren, Anders; Albertsson, Ann-Christine; Zhang, Yanzhen and Bjursten, Lars Magnus LU (1994) In Journal of Biomaterials Science. Polymer Edition 6(5). p.411-423
Abstract
Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the... (More)
Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Degradation, In vivo, copolymers, polyesters, aliphatic
in
Journal of Biomaterials Science. Polymer Edition
volume
6
issue
5
pages
411 - 423
publisher
VSP BV
external identifiers
  • pmid:7841148
  • scopus:84947384287
ISSN
0920-5063
DOI
10.1163/156856294X00400
language
English
LU publication?
yes
id
b19973bf-aaee-4f9d-a8fd-791e9c7690f0 (old id 1107765)
date added to LUP
2008-07-22 14:52:35
date last changed
2017-01-01 07:25:06
@article{b19973bf-aaee-4f9d-a8fd-791e9c7690f0,
  abstract     = {Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one.},
  author       = {Löfgren, Anders and Albertsson, Ann-Christine and Zhang, Yanzhen and Bjursten, Lars Magnus},
  issn         = {0920-5063},
  keyword      = {Degradation,In vivo,copolymers,polyesters,aliphatic},
  language     = {eng},
  number       = {5},
  pages        = {411--423},
  publisher    = {VSP BV},
  series       = {Journal of Biomaterials Science. Polymer Edition},
  title        = {Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour},
  url          = {http://dx.doi.org/10.1163/156856294X00400},
  volume       = {6},
  year         = {1994},
}