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Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation

Bjermer, Leif LU ; Sandstrom, Thomas; Särnstrand, Bengt LU and Brattsand, Ralph (1994) In American Journal of Industrial Medicine 25(1). p.73-78
Abstract
A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bronchoalveolar lavage, allergic alveolitis, eosinophils, lymphocytes, sephadex, organic dusts
in
American Journal of Industrial Medicine
volume
25
issue
1
pages
73 - 78
publisher
John Wiley & Sons
external identifiers
  • pmid:7509565
  • scopus:0028012689
ISSN
0271-3586
DOI
10.1002/ajim.4700250119
language
English
LU publication?
no
id
ba21a814-ffa1-4c1f-89d4-0d4e328dbf4d (old id 1107836)
date added to LUP
2008-07-22 15:57:58
date last changed
2017-07-30 03:32:05
@article{ba21a814-ffa1-4c1f-89d4-0d4e328dbf4d,
  abstract     = {A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.},
  author       = {Bjermer, Leif and Sandstrom, Thomas and Särnstrand, Bengt and Brattsand, Ralph},
  issn         = {0271-3586},
  keyword      = {bronchoalveolar lavage,allergic alveolitis,eosinophils,lymphocytes,sephadex,organic dusts},
  language     = {eng},
  number       = {1},
  pages        = {73--78},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation},
  url          = {http://dx.doi.org/10.1002/ajim.4700250119},
  volume       = {25},
  year         = {1994},
}