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Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation

Bjermer, Leif LU ; Sandstrom, Thomas ; Särnstrand, Bengt LU and Brattsand, Ralph (1994) In American Journal of Industrial Medicine 25(1). p.73-78
Abstract
A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bronchoalveolar lavage, allergic alveolitis, eosinophils, lymphocytes, sephadex, organic dusts
in
American Journal of Industrial Medicine
volume
25
issue
1
pages
73 - 78
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:7509565
  • scopus:0028012689
ISSN
0271-3586
DOI
10.1002/ajim.4700250119
language
English
LU publication?
no
id
ba21a814-ffa1-4c1f-89d4-0d4e328dbf4d (old id 1107836)
date added to LUP
2016-04-01 11:38:33
date last changed
2021-01-03 08:14:15
@article{ba21a814-ffa1-4c1f-89d4-0d4e328dbf4d,
  abstract     = {{A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.}},
  author       = {{Bjermer, Leif and Sandstrom, Thomas and Särnstrand, Bengt and Brattsand, Ralph}},
  issn         = {{0271-3586}},
  keywords     = {{bronchoalveolar lavage; allergic alveolitis; eosinophils; lymphocytes; sephadex; organic dusts}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{73--78}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{American Journal of Industrial Medicine}},
  title        = {{Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation}},
  url          = {{http://dx.doi.org/10.1002/ajim.4700250119}},
  doi          = {{10.1002/ajim.4700250119}},
  volume       = {{25}},
  year         = {{1994}},
}